Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993149014> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1993149014 abstract "Helicobacter pylori (H.pylori) infection is related with a high risk of Alzheimer's Disease (AD), but the intrinsic link between H.pylori infection and AD development is still missing. In the present study, we explored the effect of H.pylori infection on cognitive function and β-amyloid production in rats. Twenty-seven SD rats were randomly divided into three experimental groups (n = 9) and received intraperitoneal injection of H.pylori, E.coli filtrate or the same volume of DMEM/Opti-MEM medium as control for 7 days, the spatial learning and memory ability of the rats was tested in Morris water maze; then the rats were sacrificed for ELISA detection of brain Aβ levels and Western blotting detection of expression of related proteins such as BACE-1, presenilin (PS)-1 and PS-2. The morphology of the dendritic spines was detected by Golgi staining. N2a/APP (N2a stably transfected with human APP) cells were incubated with H.pylori filtrate, E.coli filtrate or DMEM/Opti-MEM medium for 24 hours, then the Aβ levels both in the cells and media were detected by ELISA, protein levels of BACE-1, PS-1 and PS-2 in the cells were detected by Western blotting. Intraperitoneal injection of H.pylori filtrate induced spatial learning and memory deficit in rats with a simultaneous retarded dendritic spine maturation in hippocampus. Injection of H.pylori filtrate significantly increased Aβ 42 both in the hippocampus and cortex, together with an increased level of presenilin-2 (PS-2), one key component of γ-secretase involved in Aβ production. Incubation of H.pylori filtrate with N2a cells which over-express APP also resulted in increased PS-2 expression and Aβ 42 overproduction. Injection of Escherichia.coli (E.coli) filtrate, another common intestinal bacterium, had no effect on cognitive function in rats and Aβ production in rats and cells. We conclude that soluble surface fractions of H.pylori may promote Aβ 42 formation by enhancing the activity of γ-secretase, thus induce cognitive impairment through interrupting the synaptic function." @default.
- W1993149014 created "2016-06-24" @default.
- W1993149014 creator A5013134577 @default.
- W1993149014 creator A5013900721 @default.
- W1993149014 creator A5018636031 @default.
- W1993149014 creator A5050206847 @default.
- W1993149014 creator A5050298481 @default.
- W1993149014 creator A5065591432 @default.
- W1993149014 creator A5080361329 @default.
- W1993149014 date "2014-07-01" @default.
- W1993149014 modified "2023-09-27" @default.
- W1993149014 title "P2-001: HELICOBACTER PYLORI FILTRATE IMPAIRS SPATIAL LEARNING AND MEMORY IN RATS AND INCREASES β-AMYLOID BY ENHANCING EXPRESSION OF PRESENILIN-2" @default.
- W1993149014 doi "https://doi.org/10.1016/j.jalz.2014.05.674" @default.
- W1993149014 hasPublicationYear "2014" @default.
- W1993149014 type Work @default.
- W1993149014 sameAs 1993149014 @default.
- W1993149014 citedByCount "0" @default.
- W1993149014 crossrefType "journal-article" @default.
- W1993149014 hasAuthorship W1993149014A5013134577 @default.
- W1993149014 hasAuthorship W1993149014A5013900721 @default.
- W1993149014 hasAuthorship W1993149014A5018636031 @default.
- W1993149014 hasAuthorship W1993149014A5050206847 @default.
- W1993149014 hasAuthorship W1993149014A5050298481 @default.
- W1993149014 hasAuthorship W1993149014A5065591432 @default.
- W1993149014 hasAuthorship W1993149014A5080361329 @default.
- W1993149014 hasConcept C104317684 @default.
- W1993149014 hasConcept C126322002 @default.
- W1993149014 hasConcept C153911025 @default.
- W1993149014 hasConcept C175344181 @default.
- W1993149014 hasConcept C185592680 @default.
- W1993149014 hasConcept C2776409635 @default.
- W1993149014 hasConcept C2776415932 @default.
- W1993149014 hasConcept C2779134260 @default.
- W1993149014 hasConcept C2780159080 @default.
- W1993149014 hasConcept C2781161787 @default.
- W1993149014 hasConcept C31705614 @default.
- W1993149014 hasConcept C44752575 @default.
- W1993149014 hasConcept C502032728 @default.
- W1993149014 hasConcept C55493867 @default.
- W1993149014 hasConcept C71924100 @default.
- W1993149014 hasConcept C85265743 @default.
- W1993149014 hasConcept C86803240 @default.
- W1993149014 hasConcept C98274493 @default.
- W1993149014 hasConceptScore W1993149014C104317684 @default.
- W1993149014 hasConceptScore W1993149014C126322002 @default.
- W1993149014 hasConceptScore W1993149014C153911025 @default.
- W1993149014 hasConceptScore W1993149014C175344181 @default.
- W1993149014 hasConceptScore W1993149014C185592680 @default.
- W1993149014 hasConceptScore W1993149014C2776409635 @default.
- W1993149014 hasConceptScore W1993149014C2776415932 @default.
- W1993149014 hasConceptScore W1993149014C2779134260 @default.
- W1993149014 hasConceptScore W1993149014C2780159080 @default.
- W1993149014 hasConceptScore W1993149014C2781161787 @default.
- W1993149014 hasConceptScore W1993149014C31705614 @default.
- W1993149014 hasConceptScore W1993149014C44752575 @default.
- W1993149014 hasConceptScore W1993149014C502032728 @default.
- W1993149014 hasConceptScore W1993149014C55493867 @default.
- W1993149014 hasConceptScore W1993149014C71924100 @default.
- W1993149014 hasConceptScore W1993149014C85265743 @default.
- W1993149014 hasConceptScore W1993149014C86803240 @default.
- W1993149014 hasConceptScore W1993149014C98274493 @default.
- W1993149014 hasIssue "4S_Part_12" @default.
- W1993149014 hasLocation W19931490141 @default.
- W1993149014 hasOpenAccess W1993149014 @default.
- W1993149014 hasPrimaryLocation W19931490141 @default.
- W1993149014 hasRelatedWork W1993149014 @default.
- W1993149014 hasRelatedWork W2004477997 @default.
- W1993149014 hasRelatedWork W2082044837 @default.
- W1993149014 hasRelatedWork W2357692759 @default.
- W1993149014 hasRelatedWork W2372918105 @default.
- W1993149014 hasRelatedWork W2896550264 @default.
- W1993149014 hasRelatedWork W2920618083 @default.
- W1993149014 hasRelatedWork W2963551832 @default.
- W1993149014 hasRelatedWork W2981214683 @default.
- W1993149014 hasRelatedWork W3025633179 @default.
- W1993149014 hasVolume "10" @default.
- W1993149014 isParatext "false" @default.
- W1993149014 isRetracted "false" @default.
- W1993149014 magId "1993149014" @default.
- W1993149014 workType "article" @default.