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- W1993157291 abstract "Die Chlorpyrimidine 1a,b reagieren mit nucleophilen Reagenzien zu den Substitutionsprodukten 2a–g. Die Amide 3a–h werden durch Umsetzung von 2a–g mit Ammoniak bzw. n-Propylamin erhalten. 3a–f und h lassen sich mit Natriumethanolat in die Pyrrolopyrimidine 4a–f bzw. 4h umwandeln. 4i entsteht aus 2g und n-Propylamin. Das Amid 3g sowie die Pyrrolopyrimidine 4f und 4i reagieren unter Ammoniakabspaltung zu den Siebenring-Heterocyclen 5a–c. Mit Hydrazinen setzen sich 4a–e zu Pyrimido[4,5-d]pyridazinen 6a–h um, die mit Ameisensäure, Acetanhydrid oder salpetriger Säure die Azaphenalene 7a,b,d, 8b–d und 9a–d bilden. Reactions of Chloropyrimidines, II. – Synthesis of New Diazepines and Azaphenalenes from Pyrrolo[3,4-d]pyrimidines The chloropyrimidines 1a,b react with nucleophiles to give the substitution products 2a–g. The amides 3a–h are obtained from 2a–g and ammonia or n-propylamine, respectively. Cyclisation of 3a–f and h leads to the pyrrolopyrimidines 4a–f and h. Pyrimidine 2g and n-propylamine yield 4i. Reaction of 3g or 4f and i leads to elimination of ammonia and formation of the 7-ring heterocycles 5a–c. The pyrimido[4,5-d]pyridazines 6a–h are obtained from 4a–e and hydrazines. With formic acid, acetic anhydride, or nitrous acid they are converted into the azaphenalenes 7a,b,d, 8b–d, and 9a–d." @default.
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- W1993157291 date "1988-07-14" @default.
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- W1993157291 title "Reaktionen von Chlorpyrimidinen, II Neuartige Diazepine und Azaphenalene aus Pyrrolo[3,4-d]pyrimidinen" @default.
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