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• W1993167171 abstract "Objective: To assess the effect of a helium-oxygen mixture on intubation rate and clinical outcomes during noninvasive ventilation in acute exacerbation of chronic obstructive pulmonary disease. Design: Multicenter, prospective, randomized, controlled trial. Setting: Seven intensive care units. Patients: A total of 204 patients with known or suspected chronic obstructive pulmonary disease and acute dyspnea, Paco2> 45 mm Hg and two among the following factors: pH <7.35, Paco2 <50 mm Hg, respiratory rate >25/min. Interventions: Noninvasive ventilation randomly applied with or without helium (inspired oxygen fraction 0.35) via a face mask. Measurements and Main Results: Duration and complications of NIV and mechanical ventilation, endotracheal intubation, discharge from intensive care unit and hospital, mortality at day 28, adverse and serious adverse events were recorded. Follow-up lasted until 28 days since enrollment. Intubation rate did not significantly differ between groups (24.5% vs. 30.4% with or without helium, p = .35). No difference was observed in terms of improvement of arterial blood gases, dyspnea, and respiratory rate between groups. Duration of noninvasive ventilation, length of stay, 28-day mortality, complications and adverse events were similar, although serious adverse events tended to be lower with helium (10.8% vs. 19.6%, p = .08). Conclusions: Despite small trends favoring helium, this study did not show a statistical superiority of using helium during NIV to decrease the intubation rate in acute exacerbation of chronic obstructive pulmonary disease." @default.
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• W1993167171 date "2010-01-01" @default.
• W1993167171 modified "2023-10-15" @default.
• W1993167171 title "A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease*" @default.
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• W1993167171 doi "https://doi.org/10.1097/ccm.0b013e3181b78abe" @default.
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