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• W1993170488 abstract "Every picornavirus studied thus far has a sequence within the 5'-non-coding region that is required for internal ribosome binding and translation of the polyprotein. In an attempt to identify this region in hepatitis A virus we constructed a truncated hepatitis A virus (HAV) cDNA clone that contains the entire 736 bp 5' non-coding region (5'-NCR) and 754 base pairs of the viral capsid coding region (P1) under control of the SP6 promoter. In vitro transcription and translation of this transcript in a rabbit reticulocyte lysate yielded a protein product of about 29 kDa as analyzed by autoradiography following sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS..PAGE). A series of mutations of this construct have defined a minimal sequence between bases 347 and 734 in the 5'-NCR that is required for efficient in vitro translation. The deleted constructs (D 523–734 and D 632–734) showed a reduced ability to translate in the rabbit reticulocyte lysate system in comparison with the full-length 5'-NCR construct, pH1489. The translation of these deleted constructs was artificially restored by the addition of a 5'-terminal methylated cap structure, m7GpppG, to the RNA. This increase in translational efficiency could be competed away with cap analog (m7GDP) thus indicating that this region is required for cap-independent internal ribosome binding for HAV translation." @default.
• W1993170488 created "2016-06-24" @default.
• W1993170488 creator A5000400489 @default.
• W1993170488 creator A5057060018 @default.
• W1993170488 date "1992-10-01" @default.
• W1993170488 modified "2023-09-23" @default.
• W1993170488 title "A cis-acting element within the hepatitis A virus 5'-non-coding region required for in vitro translation" @default.
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• W1993170488 doi "https://doi.org/10.1016/0168-1702(92)90143-w" @default.
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