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- W1993171330 abstract "There is limited data on effects of LNG on endometrial gene expression1; almost no information is available on effects of a LNG IUS on global endometrial gene expression in regards to genes associated with embryo implantation.2 Prospective, nonrandomized, open-label study. Baseline served as the control. We characterized gene expression in endometrial samples from women (n=6) with normal pelvic anatomy and normal menstrual cycles before LNG IUS insertion (cycle day 5-10), 10-12 days after insertion, three weeks after insertion, and three months after insertion. Endometrial biopsies were collected, mRNA was extracted and isolated, and RNA quality was calculated. The microarray performed was Agilent Whole Gene Expression 60K. T-Test and multiple hypothesis tests were used. We compared genes with at least a fold change (FC) of two. The number of genes differentially expressed with a FC >|2.0| are listed in the table. We compared these genes at each time point and found 21 dys-regulated genes in common. The PubMatrix database was used to identify the roles of the common 21 dys-regulated genes in endometrial physiology. A total of seven genes were noted in the database when the search terms “endometrial receptivity” or “implantation” were entered.Table 1Time from Baseline# Total Genes Dys-regulated# Up Regulated# Down Regulated10-12 Days212831293 Weeks132291033 Months439156283Common Genes Up RegulatedCommon Genes Down RegulatedGALNTL2, NNMT, NFIL3, FKBP5RGS7BP, MSX2P1, PLCB1, MCM2, CHAF1B, BLM, MCM3, KIF24, PCNA, RNFT2, TIMELESS, MCM3, CHAF1A, RNASEH2A, RMI1, C1orf112, RFC5GeneLog Change 10-12 DaysLog Change 3 WeeksLog Change 3 Months# Endometrial Receptivity Publications# Implantation PublicationsNNMT63.141.638.702FKBP57.15.3621NFIL36.55.96.901BLM-4.5-4.7-4.2013PCNA-3.5-4.2-4.65195TIMELESS-2.8-3.6-4.702RMI1-3.3-2.9-3.302 Open table in a new tab The presence of LNG IUS is associated with dys-regulation of >439 genes, of which 21 dys-regulated genes are shared amongst all time points. Of these, there is one up regulated gene associated with endometrial receptivity according to the literature, and one gene that is down regulated. There are three genes associated with implantation and that are up regulated and four genes that are down regulated." @default.
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- W1993171330 date "2014-09-01" @default.
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- W1993171330 title "Global endometrial gene expression with continuous exposure to levonorgestrel (LNG) via an intrauterine system (IUS)" @default.
- W1993171330 doi "https://doi.org/10.1016/j.fertnstert.2014.07.483" @default.
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