FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993193090> ?p ?o ?g. }

• W1993193090 endingPage "e00277" @default.
• W1993193090 startingPage "e00277" @default.
• W1993193090 abstract "Adenylyl cyclase (AC)-stimulated cAMP is a key mediator of collecting duct (CD) Na and water transport. AC isoforms 3, 4, and 6 are expressed in the CD. Our group demonstrated that AC6, but not AC3, is involved in regulating CD Na and water transport. However, the role of AC4 in such regulation remains unknown. Therefore, we generated mice with loxP-flanked critical exons in the Adcy4 gene and bred with mice expressing the aquaporin-2/Cre recombinase transgene to yield CD principal cell-specific knockout of AC4 (CD AC4 KO). Isolated inner medullary CD showed 100% genomic target gene recombination in CD AC4 KO mice, while microdissected cortical CD and renal papillary AC4 mRNA was significantly reduced in CD AC4 KO mice. CD AC4 KO had no effect on vasopressin (AVP)-stimulated cAMP generation in the inner medulla. Water intake, urine volume, and urine osmolality were similar between CD AC4 KO and control mice during normal or restricted water intake. Sodium intake, urinary Na excretion, and blood pressure on a normal-, high-, or low-Na diet were not affected by CD AC4 KO. Moreover, there were no differences in plasma AVP or plasma renin concentration between CD AC4 KO and control mice. In summary, these data suggest that CD AC4 does not play a role in the physiologic regulation of CD Na and water handling." @default.
• W1993193090 created "2016-06-24" @default.
• W1993193090 creator A5015774795 @default.
• W1993193090 creator A5075086560 @default.
• W1993193090 creator A5084452254 @default.
• W1993193090 date "2014-03-01" @default.
• W1993193090 modified "2023-10-16" @default.
• W1993193090 title "Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling" @default.
• W1993193090 cites W1531832162 @default.
• W1993193090 cites W1964959104 @default.
• W1993193090 cites W1966169586 @default.
• W1993193090 cites W1968902353 @default.
• W1993193090 cites W1972870617 @default.
• W1993193090 cites W1973574957 @default.
• W1993193090 cites W1976886867 @default.
• W1993193090 cites W2008374286 @default.
• W1993193090 cites W2020060900 @default.
• W1993193090 cites W2032418184 @default.
• W1993193090 cites W2039159417 @default.
• W1993193090 cites W2042950885 @default.
• W1993193090 cites W2046155443 @default.
• W1993193090 cites W2048346342 @default.
• W1993193090 cites W2055802786 @default.
• W1993193090 cites W2055951748 @default.
• W1993193090 cites W2079542777 @default.
• W1993193090 cites W2094733929 @default.
• W1993193090 cites W2097404580 @default.
• W1993193090 cites W2101119530 @default.
• W1993193090 cites W2101769129 @default.
• W1993193090 cites W2102912801 @default.
• W1993193090 cites W2105951582 @default.
• W1993193090 cites W2117729827 @default.
• W1993193090 cites W2128741046 @default.
• W1993193090 cites W2137061543 @default.
• W1993193090 cites W2137964475 @default.
• W1993193090 cites W2164190508 @default.
• W1993193090 cites W2171005064 @default.
• W1993193090 cites W2267153832 @default.
• W1993193090 cites W2372856478 @default.
• W1993193090 cites W4297361592 @default.
• W1993193090 doi "https://doi.org/10.1002/phy2.277" @default.
• W1993193090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4002255" @default.
• W1993193090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24760529" @default.
• W1993193090 hasPublicationYear "2014" @default.
• W1993193090 type Work @default.
• W1993193090 sameAs 1993193090 @default.
• W1993193090 citedByCount "7" @default.
• W1993193090 countsByYear W19931930902016 @default.
• W1993193090 countsByYear W19931930902017 @default.
• W1993193090 countsByYear W19931930902020 @default.
• W1993193090 countsByYear W19931930902022 @default.
• W1993193090 crossrefType "journal-article" @default.
• W1993193090 hasAuthorship W1993193090A5015774795 @default.
• W1993193090 hasAuthorship W1993193090A5075086560 @default.
• W1993193090 hasAuthorship W1993193090A5084452254 @default.
• W1993193090 hasBestOaLocation W19931930901 @default.
• W1993193090 hasConcept C104317684 @default.
• W1993193090 hasConcept C126322002 @default.
• W1993193090 hasConcept C134018914 @default.
• W1993193090 hasConcept C182704531 @default.
• W1993193090 hasConcept C185592680 @default.
• W1993193090 hasConcept C24998067 @default.
• W1993193090 hasConcept C2776370428 @default.
• W1993193090 hasConcept C2779178603 @default.
• W1993193090 hasConcept C55493867 @default.
• W1993193090 hasConcept C71924100 @default.
• W1993193090 hasConcept C86803240 @default.
• W1993193090 hasConceptScore W1993193090C104317684 @default.
• W1993193090 hasConceptScore W1993193090C126322002 @default.
• W1993193090 hasConceptScore W1993193090C134018914 @default.
• W1993193090 hasConceptScore W1993193090C182704531 @default.
• W1993193090 hasConceptScore W1993193090C185592680 @default.
• W1993193090 hasConceptScore W1993193090C24998067 @default.
• W1993193090 hasConceptScore W1993193090C2776370428 @default.
• W1993193090 hasConceptScore W1993193090C2779178603 @default.
• W1993193090 hasConceptScore W1993193090C55493867 @default.
• W1993193090 hasConceptScore W1993193090C71924100 @default.
• W1993193090 hasConceptScore W1993193090C86803240 @default.
• W1993193090 hasFunder F4320306127 @default.
• W1993193090 hasFunder F4320332161 @default.
• W1993193090 hasIssue "3" @default.
• W1993193090 hasLocation W19931930901 @default.
• W1993193090 hasLocation W19931930902 @default.
• W1993193090 hasLocation W19931930903 @default.
• W1993193090 hasLocation W19931930904 @default.
• W1993193090 hasOpenAccess W1993193090 @default.
• W1993193090 hasPrimaryLocation W19931930901 @default.
• W1993193090 hasRelatedWork W1964203047 @default.
• W1993193090 hasRelatedWork W1964293580 @default.
• W1993193090 hasRelatedWork W2009418740 @default.
• W1993193090 hasRelatedWork W2044402316 @default.
• W1993193090 hasRelatedWork W2057585929 @default.
• W1993193090 hasRelatedWork W2089540576 @default.
• W1993193090 hasRelatedWork W2114001827 @default.
• W1993193090 hasRelatedWork W2125760734 @default.
• W1993193090 hasRelatedWork W2281410802 @default.
• W1993193090 hasRelatedWork W3084090913 @default.
• W1993193090 hasVolume "2" @default.

• next