FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993193717> ?p ?o ?g. }

• W1993193717 endingPage "110" @default.
• W1993193717 startingPage "106" @default.
• W1993193717 abstract "Histone acetyltransferases (HATs) are important chromatin modifying enzymes that catalyze acetylation of specific lysine residues in histone and nonhistone substrates. They participate in multiple cellular processes such as transcriptional regulation and signal transduction. Aberrant expression of HATs has been observed in various disease states, especially cancer. However, current strategies used for studying HAT enzymatic activity and inhibitor discovery are quite limited. We report here a novel strategy for the homogeneous, continuous, one-step measurement of HAT activity. A series of fluorescent reporters based on the amino-terminal seqence of histone H4 were synthesized and evaluated for HAT assay. Fluorescence signals change effectively in response to the acetylation process by HAT p300. Such an assay should thus be broadly useful for assaying HAT activity in vitro as well as valuable in discovering new anticancer drugs based on the modulation of the HAT targets." @default.
• W1993193717 created "2016-06-24" @default.
• W1993193717 creator A5024191444 @default.
• W1993193717 creator A5075066562 @default.
• W1993193717 date "2008-09-01" @default.
• W1993193717 modified "2023-09-24" @default.
• W1993193717 title "Fluorescent reporters of the histone acetyltransferase" @default.
• W1993193717 cites W1534367952 @default.
• W1993193717 cites W1585805111 @default.
• W1993193717 cites W1593144410 @default.
• W1993193717 cites W1926638730 @default.
• W1993193717 cites W1963870175 @default.
• W1993193717 cites W1964249723 @default.
• W1993193717 cites W1974384304 @default.
• W1993193717 cites W1992902970 @default.
• W1993193717 cites W2002698073 @default.
• W1993193717 cites W2002900567 @default.
• W1993193717 cites W2009981313 @default.
• W1993193717 cites W2024626770 @default.
• W1993193717 cites W2025838418 @default.
• W1993193717 cites W2026631193 @default.
• W1993193717 cites W2029175848 @default.
• W1993193717 cites W2036874847 @default.
• W1993193717 cites W2049986428 @default.
• W1993193717 cites W2074129822 @default.
• W1993193717 cites W2075907707 @default.
• W1993193717 cites W2080856830 @default.
• W1993193717 cites W2081195534 @default.
• W1993193717 cites W2095050846 @default.
• W1993193717 cites W2096501714 @default.
• W1993193717 cites W2146295849 @default.
• W1993193717 cites W2157830796 @default.
• W1993193717 cites W2324032914 @default.
• W1993193717 cites W3005435921 @default.
• W1993193717 cites W4233036449 @default.
• W1993193717 doi "https://doi.org/10.1016/j.ab.2008.05.030" @default.
• W1993193717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18558077" @default.
• W1993193717 hasPublicationYear "2008" @default.
• W1993193717 type Work @default.
• W1993193717 sameAs 1993193717 @default.
• W1993193717 citedByCount "22" @default.
• W1993193717 countsByYear W19931937172012 @default.
• W1993193717 countsByYear W19931937172015 @default.
• W1993193717 countsByYear W19931937172016 @default.
• W1993193717 countsByYear W19931937172017 @default.
• W1993193717 countsByYear W19931937172018 @default.
• W1993193717 countsByYear W19931937172019 @default.
• W1993193717 countsByYear W19931937172020 @default.
• W1993193717 countsByYear W19931937172021 @default.
• W1993193717 countsByYear W19931937172023 @default.
• W1993193717 crossrefType "journal-article" @default.
• W1993193717 hasAuthorship W1993193717A5024191444 @default.
• W1993193717 hasAuthorship W1993193717A5075066562 @default.
• W1993193717 hasConcept C104317684 @default.
• W1993193717 hasConcept C119157956 @default.
• W1993193717 hasConcept C181199279 @default.
• W1993193717 hasConcept C185592680 @default.
• W1993193717 hasConcept C2776016237 @default.
• W1993193717 hasConcept C2778001298 @default.
• W1993193717 hasConcept C2779649592 @default.
• W1993193717 hasConcept C2910921701 @default.
• W1993193717 hasConcept C515207424 @default.
• W1993193717 hasConcept C552990157 @default.
• W1993193717 hasConcept C55493867 @default.
• W1993193717 hasConcept C64927066 @default.
• W1993193717 hasConcept C83640560 @default.
• W1993193717 hasConcept C86803240 @default.
• W1993193717 hasConceptScore W1993193717C104317684 @default.
• W1993193717 hasConceptScore W1993193717C119157956 @default.
• W1993193717 hasConceptScore W1993193717C181199279 @default.
• W1993193717 hasConceptScore W1993193717C185592680 @default.
• W1993193717 hasConceptScore W1993193717C2776016237 @default.
• W1993193717 hasConceptScore W1993193717C2778001298 @default.
• W1993193717 hasConceptScore W1993193717C2779649592 @default.
• W1993193717 hasConceptScore W1993193717C2910921701 @default.
• W1993193717 hasConceptScore W1993193717C515207424 @default.
• W1993193717 hasConceptScore W1993193717C552990157 @default.
• W1993193717 hasConceptScore W1993193717C55493867 @default.
• W1993193717 hasConceptScore W1993193717C64927066 @default.
• W1993193717 hasConceptScore W1993193717C83640560 @default.
• W1993193717 hasConceptScore W1993193717C86803240 @default.
• W1993193717 hasIssue "1" @default.
• W1993193717 hasLocation W19931937171 @default.
• W1993193717 hasLocation W19931937172 @default.
• W1993193717 hasOpenAccess W1993193717 @default.
• W1993193717 hasPrimaryLocation W19931937171 @default.
• W1993193717 hasRelatedWork W1963654551 @default.
• W1993193717 hasRelatedWork W1966857470 @default.
• W1993193717 hasRelatedWork W2010105460 @default.
• W1993193717 hasRelatedWork W2037579319 @default.
• W1993193717 hasRelatedWork W2155926226 @default.
• W1993193717 hasRelatedWork W2166811471 @default.
• W1993193717 hasRelatedWork W2620472692 @default.
• W1993193717 hasRelatedWork W2886655229 @default.
• W1993193717 hasRelatedWork W3206112179 @default.
• W1993193717 hasRelatedWork W4224926712 @default.
• W1993193717 hasVolume "380" @default.
• W1993193717 isParatext "false" @default.

• next