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• W1993198310 abstract "The effects of bile acids on cytosolic free calcium([Ca2+]i) were studied in single isolated rat hepatocyte couplets using a scanning laser cytometer and the fluorescent dye, indo-1. Cholestatic bile acids, chenodeoxycholate (CDC) and taurolithocholate (TLC) increased [Ca2+]i in a dose-dependent manner. Choleretic bile acids, tauroursodeoxycholate (TUDC) and taurocholate (TC), did not induce any change in [Ca2+]i except TC at very high doses. Treatment with TUDC added concomitantly with CDC or TLC significantly decreased the rise in [Ca2+]i induced by bile acids. These results, obtained with a polarized hepatocyte model that secretes bile, confirmed that cholestatic bile acids increase [Ca2+]i and showed that TUDC inhibits this phenomenon. These data are in agreement with a key role of intracellular calcium in cholestasis." @default.
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• W1993198310 date "1993-01-01" @default.
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• W1993198310 title "Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets" @default.
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• W1993198310 doi "https://doi.org/10.1016/0006-2952(93)90063-3" @default.
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