Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993201929> ?p ?o ?g. }
- W1993201929 abstract "Abstract Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-phosphate receptor. Furthermore, retromer is also required for the endosomal recruitment of the actin nucleation promoting WASH complex. The VPS35 D620N mutation causes a rare form of autosomal-dominant Parkinson’s disease (PD). Here we show that this mutant associates poorly with the WASH complex and impairs WASH recruitment to endosomes. Autophagy is impaired in cells expressing PD-mutant VPS35 or lacking WASH. The autophagy defects can be explained, at least in part, by abnormal trafficking of the autophagy protein ATG9A. Thus, the PD-causing D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation." @default.
- W1993201929 created "2016-06-24" @default.
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- W1993201929 date "2014-05-13" @default.
- W1993201929 modified "2023-10-10" @default.
- W1993201929 title "Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy" @default.
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- W1993201929 doi "https://doi.org/10.1038/ncomms4828" @default.
- W1993201929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4024763" @default.
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- W1993201929 hasPublicationYear "2014" @default.
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