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• W1993210596 abstract "With continued development and improvement of tissue engineering therapies for small articular lesions, increased attention is being focused on the challenge of engineering partial or whole synovial joints. Joint-scale constructs could have applications in the treatment of large areas of articular damage or in biological arthroplasty of severely degenerate joints. This review considers the roles of shape, loading and motion in synovial joint mechanobiology and their incorporation into the design, fabrication, and testing of engineered partial or whole joints. Incidence of degeneration, degree of impairment, and efficacy of current treatments are critical factors in choosing a target for joint bioengineering. The form and function of native joints may guide the design of engineered joint-scale constructs with respect to size, shape, and maturity. Fabrication challenges for joint-scale engineering include controlling chemo-mechano-biological microenvironments to promote the development and growth of multiple tissues with integrated interfaces or lubricated surfaces into anatomical shapes, and developing joint-scale bioreactors which nurture and stimulate the tissue with loading and motion. Finally, evaluation of load-bearing and tribological properties can range from tissue to joint scale and can focus on biological structure at present or after adaptation." @default.
• W1993210596 created "2016-06-24" @default.
• W1993210596 creator A5000662848 @default.
• W1993210596 creator A5026261610 @default.
• W1993210596 creator A5026308037 @default.
• W1993210596 creator A5032612914 @default.
• W1993210596 creator A5063903099 @default.
• W1993210596 creator A5070129487 @default.
• W1993210596 creator A5074139800 @default.
• W1993210596 date "2010-01-01" @default.
• W1993210596 modified "2023-09-26" @default.
• W1993210596 title "Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints" @default.
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