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- W1993217079 abstract "Advances in experimental tools have allowed for the systematic identification of components and biological processes as well as quantification of their activities over time. Together with computational analysis, these measurement and perturbation technologies have given rise to the field of systems biology, which seeks to discover, analyze and model the interactions of physical components in a biological system. Although in its infancy, recent application of this approach has resulted in novel insights into the machinery that regulates and modifies innate immune cell functions. Here, we summarize contributions that have been made through the unbiased interrogation of the mammalian innate immune system, emphasizing the importance of integrating orthogonal datasets into models. To enable application of approaches more broadly, however, a concerted effort across the immunology community to develop reagent and tool platforms will be required." @default.
- W1993217079 created "2016-06-24" @default.
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- W1993217079 date "2011-02-01" @default.
- W1993217079 modified "2023-10-11" @default.
- W1993217079 title "Systems biology approaches to dissect mammalian innate immunity" @default.
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- W1993217079 doi "https://doi.org/10.1016/j.coi.2010.10.022" @default.
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