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- W1993234733 endingPage "771" @default.
- W1993234733 startingPage "763" @default.
- W1993234733 abstract "During normal pregnancy, the renin-angiotensin system (RAS) plays a vitally important role in salt balance and subsequent well-being of mother and fetus. In this balance, one must consider not only the classical renal RAS but also that of the uteroplacental unit, where both maternal and fetal tissues contribute to the signaling cascade. Many studies have shown that in normal pregnancy there is an increase in almost all of the components of the RAS. In derangements of pregnancy this delicate equilibrium can become unbalanced. Preeclampsia is one such case. It is a disorder of pregnancy characterized by hypertension, proteinuria and placental abnormalities associated with shallow trophoblast invasion and impaired spiral artery remodeling. Despite being a leading cause of maternal death and a major contributor to maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are poorly understood. Immunological mechanisms and the RAS have been long considered to be involved in the development of preeclampsia. Numerous recent studies demonstrate the presence of the angiotensin II type I receptor agonistic autoantibody (AT1-AA). This autoantibody can induce many key features of the disorder and upregulate molecules involved in the pathogenesis of preeclampsia. Here we review the functional role of the RAS during pregnancy and the impact of AT1-AA on preeclampsia." @default.
- W1993234733 created "2016-06-24" @default.
- W1993234733 creator A5009800945 @default.
- W1993234733 creator A5087986796 @default.
- W1993234733 date "2008-09-01" @default.
- W1993234733 modified "2023-10-16" @default.
- W1993234733 title "The Functional Role of the Renin–Angiotensin System in Pregnancy and Preeclampsia" @default.
- W1993234733 cites W1521804991 @default.
- W1993234733 cites W1563194902 @default.
- W1993234733 cites W1975705120 @default.
- W1993234733 cites W1976714485 @default.
- W1993234733 cites W1978336879 @default.
- W1993234733 cites W1978675308 @default.
- W1993234733 cites W1982038074 @default.
- W1993234733 cites W1983186128 @default.
- W1993234733 cites W1984412550 @default.
- W1993234733 cites W1984970610 @default.
- W1993234733 cites W1985034480 @default.
- W1993234733 cites W1985379157 @default.
- W1993234733 cites W1986469266 @default.
- W1993234733 cites W1987023513 @default.
- W1993234733 cites W1989472146 @default.
- W1993234733 cites W1993504420 @default.
- W1993234733 cites W1994182601 @default.
- W1993234733 cites W1994865551 @default.
- W1993234733 cites W1996178632 @default.
- W1993234733 cites W1996686380 @default.
- W1993234733 cites W2001600264 @default.
- W1993234733 cites W2007810215 @default.
- W1993234733 cites W2012726818 @default.
- W1993234733 cites W2014871892 @default.
- W1993234733 cites W2014894250 @default.
- W1993234733 cites W2018240474 @default.
- W1993234733 cites W2019042322 @default.
- W1993234733 cites W2020953798 @default.
- W1993234733 cites W2021003600 @default.
- W1993234733 cites W2025961381 @default.
- W1993234733 cites W2026001606 @default.
- W1993234733 cites W2026038921 @default.
- W1993234733 cites W2028963449 @default.
- W1993234733 cites W2029058414 @default.
- W1993234733 cites W2031248838 @default.
- W1993234733 cites W2032095810 @default.
- W1993234733 cites W2032882287 @default.
- W1993234733 cites W2041517672 @default.
- W1993234733 cites W2044576639 @default.
- W1993234733 cites W2050087753 @default.
- W1993234733 cites W2051213492 @default.
- W1993234733 cites W2053976090 @default.
- W1993234733 cites W2057167003 @default.
- W1993234733 cites W2057921565 @default.
- W1993234733 cites W2061303273 @default.
- W1993234733 cites W2062965113 @default.
- W1993234733 cites W2065995352 @default.
- W1993234733 cites W2066124973 @default.
- W1993234733 cites W2067791130 @default.
- W1993234733 cites W2070539370 @default.
- W1993234733 cites W2078232348 @default.
- W1993234733 cites W2079249388 @default.
- W1993234733 cites W2080640965 @default.
- W1993234733 cites W2082757943 @default.
- W1993234733 cites W2083507401 @default.
- W1993234733 cites W2089221056 @default.
- W1993234733 cites W2090330461 @default.
- W1993234733 cites W2092199997 @default.
- W1993234733 cites W2094004889 @default.
- W1993234733 cites W2094252521 @default.
- W1993234733 cites W2094462113 @default.
- W1993234733 cites W2097728608 @default.
- W1993234733 cites W2102277066 @default.
- W1993234733 cites W2105220773 @default.
- W1993234733 cites W2113017327 @default.
- W1993234733 cites W2114519926 @default.
- W1993234733 cites W2117431149 @default.
- W1993234733 cites W2118531357 @default.
- W1993234733 cites W2119043639 @default.
- W1993234733 cites W2119084006 @default.
- W1993234733 cites W2129832021 @default.
- W1993234733 cites W2132098153 @default.
- W1993234733 cites W2134319114 @default.
- W1993234733 cites W2135510131 @default.
- W1993234733 cites W2136268541 @default.
- W1993234733 cites W2140785684 @default.
- W1993234733 cites W2143180984 @default.
- W1993234733 cites W2143764193 @default.
- W1993234733 cites W2145729033 @default.
- W1993234733 cites W2149962573 @default.
- W1993234733 cites W2156182815 @default.
- W1993234733 cites W2156835401 @default.
- W1993234733 cites W2158254997 @default.
- W1993234733 cites W2160705469 @default.
- W1993234733 cites W2162445261 @default.
- W1993234733 cites W2164330385 @default.
- W1993234733 cites W2164878633 @default.
- W1993234733 cites W2167230754 @default.
- W1993234733 cites W2326184555 @default.
- W1993234733 cites W2399906301 @default.
- W1993234733 cites W4249180634 @default.