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• W1993236717 abstract "We currently recognize five large ubiquitous superfamilies and one small eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the ABC superfamily, includes members that use ATP hydrolysis to drive drug efflux, but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, functioning by drug:H(+)or drug:Na(+)antiport mechanisms. The small MET family seems to be restricted to endosomal membranes of eukaryotes, and only a single such system has been functionally characterized. In this review article, these families of drug transporters are discussed and evaluated from phylogenetic standpoints." @default.
• W1993236717 created "2016-06-24" @default.
• W1993236717 creator A5063618841 @default.
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• W1993236717 date "2001-06-01" @default.
• W1993236717 modified "2023-10-14" @default.
• W1993236717 title "Phylogeny of multidrug transporters" @default.
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• W1993236717 doi "https://doi.org/10.1006/scdb.2000.0246" @default.
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