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- W1993237312 abstract "A self-assembled Fmoc-peptide hydrogel has been interfaced with a liquid crystal (LC) display to give an optical sensor for enzyme activity. An Fmoc-TL-OMe hydrogel was selected as it can be formed in situ by enzyme-mediated assembly with thermolysin, and undergoes enzyme-mediated diassembly upon subtilisin addition. This enzyme-responsive hydrogel provides a semi-rigid, highly hydrated and biocompatible environment that also holds the LC display in place. A dual layer design was developed, where a phospholipid-loaded upper gel layer was separated from the LC display by a phospholipid free lower layer. Subtilisin (0.15 μM) digested both layers to give a gel-to-sol transition after several hours that liberated the phospholipid and produced a light-to-dark optical change in the LC display. The optical response was dependent upon the gel-to-sol transition; elastase or common components of serum did not disassemble the Fmoc-TL-OMe hydrogel and did not give an optical response." @default.
- W1993237312 created "2016-06-24" @default.
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- W1993237312 date "2013-01-01" @default.
- W1993237312 modified "2023-09-27" @default.
- W1993237312 title "Interfacing biodegradable molecular hydrogels with liquid crystals" @default.
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- W1993237312 doi "https://doi.org/10.1039/c2sm27160e" @default.
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