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- W1993239839 abstract "Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be involved in the pathogenesis of IR. In this study, we aim to investigate the concentrations of plasma progranulin in Chinese patients with obesity (OB) and type 2 diabetes mellitus (T2DM), and its relationship to IR. Plasma progranulin concentrations were significantly higher in the T2DM patients than in the normal glucose tolerant (NGT) subjects (<svg style=vertical-align:-0.1638pt;width:58.712502px; id=M1 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><path id=x1D443 d=M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z /></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><path id=x3C d=M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z /></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><path id=x30 d=M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z /></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><path id=x2E d=M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z /></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><path id=x31 d=M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z /></g> </svg>). Within the T2DM and the NGT patients, the concentrations of progranulin were significantly higher in obese subjects than that in the normal weight subjects (225.22 ± 34.39 ng/mL versus 195.59 ± 50.47 ng/mL and 183.79 ± 61.63 ng/mL versus 148.69 ± 55.27 ng/mL, <svg style=vertical-align:-0.1638pt;width:58.712502px; id=M2 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><path id=x35 d=M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
l-26 -65h-233z /></g> </svg>). Plasma progranulin concentrations correlated positively with weight, waist circumferences, BMI, HbA1c, TG, IL-6, FINS and HOMA-IR (<svg style=vertical-align:-0.1638pt;width:58.712502px; id=M3 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x35/></g> </svg>), while correlated negatively with HOMA-<i >β</i> (<svg style=vertical-align:-0.1638pt;width:58.712502px; id=M4 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x35/></g> </svg>). Multiple linear regression analysis showed that BMI, HbA1c, IL-6 and TG correlated independently with circulating progranulin concentrations (<svg style=vertical-align:-0.1638pt;width:58.712502px; id=M5 height=11.375 version=1.1 viewBox=0 0 58.712502 11.375 width=58.712502 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><use xlink:href=#x1D443/></g><g transform=matrix(.017,-0,0,-.017,15.582,11.112)><use xlink:href=#x3C/></g><g transform=matrix(.017,-0,0,-.017,30.286,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,38.446,11.112)><use xlink:href=#x2E/></g><g transform=matrix(.017,-0,0,-.017,42.321,11.112)><use xlink:href=#x30/></g><g transform=matrix(.017,-0,0,-.017,50.481,11.112)><use xlink:href=#x35/></g> </svg>). These results suggested that Plasma progranulin concentrations were higher in Chinese patients with type 2 diabetes and obesity and correlated closely with glycolipid metabolism, chronic inflammation and IR." @default.
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- W1993239839 date "2013-01-01" @default.
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- W1993239839 title "Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance" @default.
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