Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993239968> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1993239968 endingPage "319" @default.
- W1993239968 startingPage "313" @default.
- W1993239968 abstract "Pharmacokinetics together with in vivo metabolism and elimination of quinlukast, a potential anti-asthmatic and anti-inflammatory drug, were designed in rats. For this purpose, bile duct cannulated rats and an in situ perfused rat liver preparation were employed. 3H-radiolabelled compound was administered i.v. or loaded to the perfusion medium, respectively. Quinlukast represented the main form of radioactivity determined in plasma; in comparison with the parent drug metabolites were present in lower levels in the systemic circulation. The pharmacokinetic parameters related to the whole animal were calculated from quinlukast rat plasma concentration–time course. The distribution of quinlukast in the body was relatively fast (distribution half-life was approx. 6 min), the elimination half-life exceeded 2 h. Binding of quinlukast to rat plasma proteins was very high (approx. 99.7%) and this binding influenced distribution volumes of quinlukast. Both the volume of the central compartment and the volume at a steady state were approx. 115 and 430 ml, respectively. The experiments showed that the biliary clearance was the major route of elimination of this compound from the systemic circulation of rats. In agreement with the determined elimination half-life approx. 42% of the radioactivity was found in the bile, with <0.5% appearing in the urine. The majority of the eliminated radioactivity in the bile was in the form of polar metabolites; only a small part of the parent compound was determined. Two hours after intravenous administration, polar metabolites – but no parent drug – were detected in the urine." @default.
- W1993239968 created "2016-06-24" @default.
- W1993239968 creator A5017133156 @default.
- W1993239968 creator A5040308915 @default.
- W1993239968 creator A5050193895 @default.
- W1993239968 date "2005-06-01" @default.
- W1993239968 modified "2023-09-26" @default.
- W1993239968 title "Pharmacokinetics of radiolabelled quinlukast in rats" @default.
- W1993239968 cites W1558807891 @default.
- W1993239968 cites W1844571272 @default.
- W1993239968 cites W1967529502 @default.
- W1993239968 cites W1990971628 @default.
- W1993239968 cites W1997364324 @default.
- W1993239968 cites W1998644167 @default.
- W1993239968 cites W1998665898 @default.
- W1993239968 cites W2049114017 @default.
- W1993239968 cites W2052365733 @default.
- W1993239968 cites W2067602209 @default.
- W1993239968 cites W2070693027 @default.
- W1993239968 cites W2073124486 @default.
- W1993239968 cites W2085714213 @default.
- W1993239968 cites W2087526401 @default.
- W1993239968 cites W2092837066 @default.
- W1993239968 cites W2123573340 @default.
- W1993239968 cites W2142635246 @default.
- W1993239968 cites W571870702 @default.
- W1993239968 cites W76304320 @default.
- W1993239968 doi "https://doi.org/10.1016/j.jpba.2005.01.011" @default.
- W1993239968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15925224" @default.
- W1993239968 hasPublicationYear "2005" @default.
- W1993239968 type Work @default.
- W1993239968 sameAs 1993239968 @default.
- W1993239968 citedByCount "1" @default.
- W1993239968 crossrefType "journal-article" @default.
- W1993239968 hasAuthorship W1993239968A5017133156 @default.
- W1993239968 hasAuthorship W1993239968A5040308915 @default.
- W1993239968 hasAuthorship W1993239968A5050193895 @default.
- W1993239968 hasConcept C110121322 @default.
- W1993239968 hasConcept C112705442 @default.
- W1993239968 hasConcept C134306372 @default.
- W1993239968 hasConcept C139254425 @default.
- W1993239968 hasConcept C150903083 @default.
- W1993239968 hasConcept C185592680 @default.
- W1993239968 hasConcept C207001950 @default.
- W1993239968 hasConcept C2778620825 @default.
- W1993239968 hasConcept C2780026642 @default.
- W1993239968 hasConcept C33923547 @default.
- W1993239968 hasConcept C3941253 @default.
- W1993239968 hasConcept C43617362 @default.
- W1993239968 hasConcept C55493867 @default.
- W1993239968 hasConcept C62231903 @default.
- W1993239968 hasConcept C71924100 @default.
- W1993239968 hasConcept C86803240 @default.
- W1993239968 hasConcept C89311334 @default.
- W1993239968 hasConcept C98274493 @default.
- W1993239968 hasConceptScore W1993239968C110121322 @default.
- W1993239968 hasConceptScore W1993239968C112705442 @default.
- W1993239968 hasConceptScore W1993239968C134306372 @default.
- W1993239968 hasConceptScore W1993239968C139254425 @default.
- W1993239968 hasConceptScore W1993239968C150903083 @default.
- W1993239968 hasConceptScore W1993239968C185592680 @default.
- W1993239968 hasConceptScore W1993239968C207001950 @default.
- W1993239968 hasConceptScore W1993239968C2778620825 @default.
- W1993239968 hasConceptScore W1993239968C2780026642 @default.
- W1993239968 hasConceptScore W1993239968C33923547 @default.
- W1993239968 hasConceptScore W1993239968C3941253 @default.
- W1993239968 hasConceptScore W1993239968C43617362 @default.
- W1993239968 hasConceptScore W1993239968C55493867 @default.
- W1993239968 hasConceptScore W1993239968C62231903 @default.
- W1993239968 hasConceptScore W1993239968C71924100 @default.
- W1993239968 hasConceptScore W1993239968C86803240 @default.
- W1993239968 hasConceptScore W1993239968C89311334 @default.
- W1993239968 hasConceptScore W1993239968C98274493 @default.
- W1993239968 hasIssue "2" @default.
- W1993239968 hasLocation W19932399681 @default.
- W1993239968 hasLocation W19932399682 @default.
- W1993239968 hasOpenAccess W1993239968 @default.
- W1993239968 hasPrimaryLocation W19932399681 @default.
- W1993239968 hasRelatedWork W1906640546 @default.
- W1993239968 hasRelatedWork W1993239968 @default.
- W1993239968 hasRelatedWork W2004556784 @default.
- W1993239968 hasRelatedWork W2015484631 @default.
- W1993239968 hasRelatedWork W2057097799 @default.
- W1993239968 hasRelatedWork W2065186562 @default.
- W1993239968 hasRelatedWork W2094329931 @default.
- W1993239968 hasRelatedWork W2114434432 @default.
- W1993239968 hasRelatedWork W2322692385 @default.
- W1993239968 hasRelatedWork W642529161 @default.
- W1993239968 hasVolume "38" @default.
- W1993239968 isParatext "false" @default.
- W1993239968 isRetracted "false" @default.
- W1993239968 magId "1993239968" @default.
- W1993239968 workType "article" @default.