FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993244384> ?p ?o ?g. }

• W1993244384 endingPage "9086" @default.
• W1993244384 startingPage "9081" @default.
• W1993244384 abstract "Spatial vision in different organisms is mediated by 2 classes of photoreceptors: microvillar and ciliary. Recently, additional photosensitive cells implicated in nonvisual light-dependent functions have been identified in the mammalian retina. A previously undescribed photopigment, melanopsin, underlies these photoresponses, and it has been proposed that its transduction mechanisms may be akin to the lipid-signaling scheme of invertebrate microvillar receptors, rather than the cyclic-nucleotide cascade of vertebrates. Melanopsin has an ancient origin in deuterostomia, and expresses in 2 morphologically distinct classes of cells in the neural tube of Amphioxus, the most basal extant chordate: pigmented ocelli, and Joseph cells. However, to our knowledge, their physiology and alleged photosensitivity had never been investigated. We dissociated both types of cells, and conclusively demonstrated by patch-electrode recoding that they are primary photoreceptors; their receptor potential is depolarizing, accompanied by an increase in membrane conductance. The action spectrum peaks in the blue region, approximately 470 nm, similar to the absorption of melanopsin in vitro. The light-dependent conductance rectifies inwardly; Na and Ca are differentially implicated in the 2 cell types. Fluorescence Ca imaging reveals that photostimulation rapidly mobilizes calcium from internal stores. Intracellular 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate severely impairs the photoresponse, indicating that light-evoked Ca elevation is an important event in photoexcitation. These observations support the notion that the lineage of microvillar photoreceptors and its associated light-signaling pathway also evolved in the chordates. Thus, Joseph cells and pigmented ocelli of the Amphioxus may represent a link between ancestral rhabdomeric-like light sensors present in prebilaterians and the circadian photoreceptors of higher vertebrates." @default.
• W1993244384 created "2016-06-24" @default.
• W1993244384 creator A5057202299 @default.
• W1993244384 creator A5073916045 @default.
• W1993244384 creator A5074250858 @default.
• W1993244384 date "2009-06-02" @default.
• W1993244384 modified "2023-09-25" @default.
• W1993244384 title "Light-transduction in melanopsin-expressing photoreceptors of Amphioxus" @default.
• W1993244384 cites W1574791065 @default.
• W1993244384 cites W1970373298 @default.
• W1993244384 cites W1971524741 @default.
• W1993244384 cites W1974192701 @default.
• W1993244384 cites W1977388717 @default.
• W1993244384 cites W1983127589 @default.
• W1993244384 cites W1984116068 @default.
• W1993244384 cites W1989665437 @default.
• W1993244384 cites W1990264305 @default.
• W1993244384 cites W1992390853 @default.
• W1993244384 cites W1992420220 @default.
• W1993244384 cites W1993228159 @default.
• W1993244384 cites W1995481744 @default.
• W1993244384 cites W1996462740 @default.
• W1993244384 cites W1998074228 @default.
• W1993244384 cites W2004248451 @default.
• W1993244384 cites W2005863765 @default.
• W1993244384 cites W2009077913 @default.
• W1993244384 cites W2026639348 @default.
• W1993244384 cites W2035853180 @default.
• W1993244384 cites W2064069419 @default.
• W1993244384 cites W2071317669 @default.
• W1993244384 cites W2072018453 @default.
• W1993244384 cites W2073028192 @default.
• W1993244384 cites W2081024860 @default.
• W1993244384 cites W2088428828 @default.
• W1993244384 cites W2094217838 @default.
• W1993244384 cites W2105050095 @default.
• W1993244384 cites W2116486508 @default.
• W1993244384 cites W2118108155 @default.
• W1993244384 cites W2126414770 @default.
• W1993244384 cites W2126435291 @default.
• W1993244384 cites W2131871062 @default.
• W1993244384 cites W2135393774 @default.
• W1993244384 cites W2141029861 @default.
• W1993244384 cites W2141959073 @default.
• W1993244384 cites W2151447895 @default.
• W1993244384 cites W2171640295 @default.
• W1993244384 cites W4247303988 @default.
• W1993244384 doi "https://doi.org/10.1073/pnas.0900708106" @default.
• W1993244384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2690026" @default.
• W1993244384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19451628" @default.
• W1993244384 hasPublicationYear "2009" @default.
• W1993244384 type Work @default.
• W1993244384 sameAs 1993244384 @default.
• W1993244384 citedByCount "40" @default.
• W1993244384 countsByYear W19932443842012 @default.
• W1993244384 countsByYear W19932443842013 @default.
• W1993244384 countsByYear W19932443842014 @default.
• W1993244384 countsByYear W19932443842015 @default.
• W1993244384 countsByYear W19932443842016 @default.
• W1993244384 countsByYear W19932443842017 @default.
• W1993244384 countsByYear W19932443842018 @default.
• W1993244384 countsByYear W19932443842019 @default.
• W1993244384 countsByYear W19932443842020 @default.
• W1993244384 countsByYear W19932443842021 @default.
• W1993244384 countsByYear W19932443842022 @default.
• W1993244384 crossrefType "journal-article" @default.
• W1993244384 hasAuthorship W1993244384A5057202299 @default.
• W1993244384 hasAuthorship W1993244384A5073916045 @default.
• W1993244384 hasAuthorship W1993244384A5074250858 @default.
• W1993244384 hasBestOaLocation W19932443841 @default.
• W1993244384 hasConcept C105702510 @default.
• W1993244384 hasConcept C12554922 @default.
• W1993244384 hasConcept C131667965 @default.
• W1993244384 hasConcept C15152581 @default.
• W1993244384 hasConcept C169760540 @default.
• W1993244384 hasConcept C170493617 @default.
• W1993244384 hasConcept C189780591 @default.
• W1993244384 hasConcept C202033177 @default.
• W1993244384 hasConcept C24639789 @default.
• W1993244384 hasConcept C2777093970 @default.
• W1993244384 hasConcept C2777624874 @default.
• W1993244384 hasConcept C2780827179 @default.
• W1993244384 hasConcept C2781151714 @default.
• W1993244384 hasConcept C30028475 @default.
• W1993244384 hasConcept C3449773 @default.
• W1993244384 hasConcept C38137364 @default.
• W1993244384 hasConcept C54355233 @default.
• W1993244384 hasConcept C55493867 @default.
• W1993244384 hasConcept C86803240 @default.
• W1993244384 hasConcept C88367079 @default.
• W1993244384 hasConcept C95444343 @default.
• W1993244384 hasConceptScore W1993244384C105702510 @default.
• W1993244384 hasConceptScore W1993244384C12554922 @default.
• W1993244384 hasConceptScore W1993244384C131667965 @default.
• W1993244384 hasConceptScore W1993244384C15152581 @default.
• W1993244384 hasConceptScore W1993244384C169760540 @default.
• W1993244384 hasConceptScore W1993244384C170493617 @default.
• W1993244384 hasConceptScore W1993244384C189780591 @default.

• next