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• W1993244611 abstract "Abstract Curcumin, an active constituent of the spice turmeric, is well known for its chemopreventive properties and is found to be beneficial in treating various disorders including skin diseases. Curcumin protects skin by quenching free radicals and reducing inflammation through the inhibition of nuclear factor‐kappa B. Curcumin also affects other signaling pathways including transforming growth factor‐β and mitogen‐activated protein kinase pathway. Curcumin also modulates the phase II detoxification enzymes which are crucial in detoxification reactions and for protection against oxidative stress. In the present review, the biological mechanisms of the chemopreventive potential of curcumin in various skin diseases like psoriasis, vitiligo, and melanoma is discussed. The application of curcumin in skin regeneration and wound healing is also elucidated. We also explored the recent innovations and advances involved in the development of transdermal delivery systems to enhance the bioavailability of curcumin, particularly in the skin. Recent clinical trials pertaining to the use of curumin in skin diseases establishes its benefits and also the need for additional clinical trials in other diseases are discussed. © 2013 BioFactors, 39(1):141–149, 2013" @default.
• W1993244611 created "2016-06-24" @default.
• W1993244611 creator A5026508305 @default.
• W1993244611 creator A5047966573 @default.
• W1993244611 creator A5060258838 @default.
• W1993244611 date "2013-01-01" @default.
• W1993244611 modified "2023-10-15" @default.
• W1993244611 title "Skin regenerative potentials of curcumin" @default.
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• W1993244611 doi "https://doi.org/10.1002/biof.1078" @default.
• W1993244611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23315856" @default.
• W1993244611 hasPublicationYear "2013" @default.
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