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- W1993249718 startingPage "139" @default.
- W1993249718 abstract "Brain atrophy caused by neuronal loss is a prominent pathological feature of Alzheimer's disease (AD). Amyloid beta (Abeta), the major component of senile plaques, is considered to play a central role in neuronal cell death. In addition to removal of the toxic Abeta, direct suppression of neuronal loss is an essential part of AD treatment; however, no such neuroprotective therapies have been developed. Excess amount of Abeta evokes multiple cytotoxic mechanisms, involving increase of the intracellular Ca(2+) level, oxidative stress, and receptor-mediated activation of cell-death cascades. Such diversity in cytotoxic mechanisms induced by Abeta clearly indicates a complex nature of the AD-related neuronal cell death. We have identified a 24-residue peptide, Humanin (HN), which suppresses in vitro neuronal cell death caused by all AD-related insults, including Abeta, so far tested. The anti-AD effect of HN has been further confirmed in vivo using mice with Abeta-induced amnesia. Altogether, such potent neuroprotective activity of HN against AD-relevant cytotoxicity both in vitro and in vivo suggests the potential clinical applications of HN in novel AD therapies aimed at controlling neuronal death." @default.
- W1993249718 created "2016-06-24" @default.
- W1993249718 creator A5002305318 @default.
- W1993249718 creator A5034227227 @default.
- W1993249718 creator A5046710756 @default.
- W1993249718 date "2006-04-01" @default.
- W1993249718 modified "2023-10-09" @default.
- W1993249718 title "Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin" @default.
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