Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993259609> ?p ?o ?g. }
- W1993259609 endingPage "e40502" @default.
- W1993259609 startingPage "e40502" @default.
- W1993259609 abstract "Pregnancy is a leading risk factor for severe complications during an influenza virus infection. Women infected during their second and third trimesters are at increased risk for severe cardiopulmonary complications, premature delivery, and death. Here, we establish a murine model of aerosolized influenza infection during pregnancy. We find significantly altered innate antiviral responses in pregnant mice, including decreased levels of IFN-β, IL-1α, and IFN-γ at early time points of infection. We also find reduced cytotoxic T cell activity and delayed viral clearance. We further demonstrate that pregnancy levels of the estrogen 17-β-estradiol are able to induce key anti-inflammatory phenotypes in immune responses to the virus independently of other hormones or pregnancy-related stressors. We conclude that elevated estrogen levels result in an attenuated anti-viral immune response, and that pregnancy-associated morbidities occur in the context of this anti-inflammatory phenotype." @default.
- W1993259609 created "2016-06-24" @default.
- W1993259609 creator A5033595795 @default.
- W1993259609 creator A5063483652 @default.
- W1993259609 creator A5075527420 @default.
- W1993259609 creator A5077956716 @default.
- W1993259609 date "2012-07-05" @default.
- W1993259609 modified "2023-10-03" @default.
- W1993259609 title "Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice" @default.
- W1993259609 cites W1530236498 @default.
- W1993259609 cites W1584802909 @default.
- W1993259609 cites W1659969636 @default.
- W1993259609 cites W1749439861 @default.
- W1993259609 cites W1843829844 @default.
- W1993259609 cites W1899873857 @default.
- W1993259609 cites W1965766684 @default.
- W1993259609 cites W1967702267 @default.
- W1993259609 cites W1972829744 @default.
- W1993259609 cites W1975461687 @default.
- W1993259609 cites W1987532375 @default.
- W1993259609 cites W1988795185 @default.
- W1993259609 cites W1989496524 @default.
- W1993259609 cites W1992428625 @default.
- W1993259609 cites W2010909983 @default.
- W1993259609 cites W2014020243 @default.
- W1993259609 cites W2018020394 @default.
- W1993259609 cites W2022431942 @default.
- W1993259609 cites W2028999489 @default.
- W1993259609 cites W2034866046 @default.
- W1993259609 cites W2037296190 @default.
- W1993259609 cites W2039364757 @default.
- W1993259609 cites W2045708535 @default.
- W1993259609 cites W2051148401 @default.
- W1993259609 cites W2054178434 @default.
- W1993259609 cites W2067604406 @default.
- W1993259609 cites W2070853749 @default.
- W1993259609 cites W2071768705 @default.
- W1993259609 cites W2076343827 @default.
- W1993259609 cites W2077691992 @default.
- W1993259609 cites W2085949544 @default.
- W1993259609 cites W2093202498 @default.
- W1993259609 cites W2095886071 @default.
- W1993259609 cites W2100786986 @default.
- W1993259609 cites W2104397221 @default.
- W1993259609 cites W2105019915 @default.
- W1993259609 cites W2105110692 @default.
- W1993259609 cites W2105598663 @default.
- W1993259609 cites W2106115061 @default.
- W1993259609 cites W2109593713 @default.
- W1993259609 cites W2114172480 @default.
- W1993259609 cites W2114275123 @default.
- W1993259609 cites W2117515288 @default.
- W1993259609 cites W2118775981 @default.
- W1993259609 cites W2119950877 @default.
- W1993259609 cites W2120783853 @default.
- W1993259609 cites W2121454015 @default.
- W1993259609 cites W2130515362 @default.
- W1993259609 cites W2132341126 @default.
- W1993259609 cites W2133630517 @default.
- W1993259609 cites W2135421762 @default.
- W1993259609 cites W2135551891 @default.
- W1993259609 cites W2141422125 @default.
- W1993259609 cites W2141889116 @default.
- W1993259609 cites W2142972284 @default.
- W1993259609 cites W2149222281 @default.
- W1993259609 cites W2149353378 @default.
- W1993259609 cites W2150249655 @default.
- W1993259609 cites W2156140162 @default.
- W1993259609 cites W2159203244 @default.
- W1993259609 cites W2159366493 @default.
- W1993259609 cites W2163369593 @default.
- W1993259609 cites W2168448634 @default.
- W1993259609 cites W2169911721 @default.
- W1993259609 cites W2172274462 @default.
- W1993259609 cites W2252876436 @default.
- W1993259609 cites W2319459971 @default.
- W1993259609 doi "https://doi.org/10.1371/journal.pone.0040502" @default.
- W1993259609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3390370" @default.
- W1993259609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22792357" @default.
- W1993259609 hasPublicationYear "2012" @default.
- W1993259609 type Work @default.
- W1993259609 sameAs 1993259609 @default.
- W1993259609 citedByCount "62" @default.
- W1993259609 countsByYear W19932596092013 @default.
- W1993259609 countsByYear W19932596092014 @default.
- W1993259609 countsByYear W19932596092015 @default.
- W1993259609 countsByYear W19932596092016 @default.
- W1993259609 countsByYear W19932596092017 @default.
- W1993259609 countsByYear W19932596092018 @default.
- W1993259609 countsByYear W19932596092019 @default.
- W1993259609 countsByYear W19932596092020 @default.
- W1993259609 countsByYear W19932596092021 @default.
- W1993259609 countsByYear W19932596092022 @default.
- W1993259609 countsByYear W19932596092023 @default.
- W1993259609 crossrefType "journal-article" @default.
- W1993259609 hasAuthorship W1993259609A5033595795 @default.
- W1993259609 hasAuthorship W1993259609A5063483652 @default.
- W1993259609 hasAuthorship W1993259609A5075527420 @default.