Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993268085> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1993268085 endingPage "2602" @default.
- W1993268085 startingPage "2595" @default.
- W1993268085 abstract "A new class of compounds was synthesized and, based on structural analogy to podophyllotoxin, examined as potential microtubule inhibitors and evaluated for in vivo antineoplastic activity. These agents are derivatives of methylenedioxy-benzopyran bearing a phenyl substituent at position 8. The hydrogen atoms at positions 7 and 8 are in a trans configuration, in contrast to the cis configuration of analogous hydrogen atoms at positions 1 and 2 in podophyllotoxin. Compounds with a variety of substituents at positions 6 and 7 were examined, as well as compounds with varying methoxy substituent patterns on the phenyl ring attached at position 8. The most active compounds inhibited tubulin polymerization at concentrations approximately stoichiometric with tubulin, competitively inhibited the binding of colchicine to tubulin, and caused mitotic arrest at cytotoxic drug concentrations. No structure-activity correlations were obvious for the substituents at positions 6 and 7, but optimal activity was only observed when the phenyl substituent at position 8 was a trimethoxybenzene ring identical to the analogous ring in podophyllotoxin (i.e. methoxy groups at positions 3', 4' and 5'). Despite their structural and functional similarities to podophyllotoxin, however, the methylenedioxy-benzopyran derivatives subtly differ from the natural product in their interaction with tubulin, for they stimulated rather than inhibited tubulin-dependent GTP hydrolysis." @default.
- W1993268085 created "2016-06-24" @default.
- W1993268085 creator A5014695465 @default.
- W1993268085 creator A5020878774 @default.
- W1993268085 creator A5063020930 @default.
- W1993268085 creator A5088149477 @default.
- W1993268085 date "1988-07-01" @default.
- W1993268085 modified "2023-09-25" @default.
- W1993268085 title "Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization" @default.
- W1993268085 cites W1974324477 @default.
- W1993268085 cites W1993950444 @default.
- W1993268085 cites W2002915546 @default.
- W1993268085 cites W2013995570 @default.
- W1993268085 cites W2014284111 @default.
- W1993268085 cites W2024304301 @default.
- W1993268085 cites W2030004024 @default.
- W1993268085 cites W2030386460 @default.
- W1993268085 cites W2033341314 @default.
- W1993268085 cites W2036321797 @default.
- W1993268085 cites W2036955785 @default.
- W1993268085 cites W2038456507 @default.
- W1993268085 cites W2040556303 @default.
- W1993268085 cites W2041206504 @default.
- W1993268085 cites W2057106900 @default.
- W1993268085 cites W2057781987 @default.
- W1993268085 cites W2063328950 @default.
- W1993268085 cites W2077779358 @default.
- W1993268085 cites W2082562172 @default.
- W1993268085 cites W2084550732 @default.
- W1993268085 cites W28555583 @default.
- W1993268085 doi "https://doi.org/10.1016/0006-2952(88)90251-1" @default.
- W1993268085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3390218" @default.
- W1993268085 hasPublicationYear "1988" @default.
- W1993268085 type Work @default.
- W1993268085 sameAs 1993268085 @default.
- W1993268085 citedByCount "28" @default.
- W1993268085 countsByYear W19932680852012 @default.
- W1993268085 countsByYear W19932680852013 @default.
- W1993268085 countsByYear W19932680852016 @default.
- W1993268085 countsByYear W19932680852017 @default.
- W1993268085 countsByYear W19932680852019 @default.
- W1993268085 countsByYear W19932680852020 @default.
- W1993268085 countsByYear W19932680852021 @default.
- W1993268085 countsByYear W19932680852022 @default.
- W1993268085 countsByYear W19932680852023 @default.
- W1993268085 crossrefType "journal-article" @default.
- W1993268085 hasAuthorship W1993268085A5014695465 @default.
- W1993268085 hasAuthorship W1993268085A5020878774 @default.
- W1993268085 hasAuthorship W1993268085A5063020930 @default.
- W1993268085 hasAuthorship W1993268085A5088149477 @default.
- W1993268085 hasConcept C178790620 @default.
- W1993268085 hasConcept C185592680 @default.
- W1993268085 hasConcept C20418707 @default.
- W1993268085 hasConcept C2776286485 @default.
- W1993268085 hasConcept C2778143360 @default.
- W1993268085 hasConcept C2778689049 @default.
- W1993268085 hasConcept C2780263894 @default.
- W1993268085 hasConcept C2780760878 @default.
- W1993268085 hasConcept C71240020 @default.
- W1993268085 hasConcept C84425145 @default.
- W1993268085 hasConcept C86803240 @default.
- W1993268085 hasConcept C90150868 @default.
- W1993268085 hasConcept C95444343 @default.
- W1993268085 hasConceptScore W1993268085C178790620 @default.
- W1993268085 hasConceptScore W1993268085C185592680 @default.
- W1993268085 hasConceptScore W1993268085C20418707 @default.
- W1993268085 hasConceptScore W1993268085C2776286485 @default.
- W1993268085 hasConceptScore W1993268085C2778143360 @default.
- W1993268085 hasConceptScore W1993268085C2778689049 @default.
- W1993268085 hasConceptScore W1993268085C2780263894 @default.
- W1993268085 hasConceptScore W1993268085C2780760878 @default.
- W1993268085 hasConceptScore W1993268085C71240020 @default.
- W1993268085 hasConceptScore W1993268085C84425145 @default.
- W1993268085 hasConceptScore W1993268085C86803240 @default.
- W1993268085 hasConceptScore W1993268085C90150868 @default.
- W1993268085 hasConceptScore W1993268085C95444343 @default.
- W1993268085 hasIssue "13" @default.
- W1993268085 hasLocation W19932680851 @default.
- W1993268085 hasLocation W19932680852 @default.
- W1993268085 hasOpenAccess W1993268085 @default.
- W1993268085 hasPrimaryLocation W19932680851 @default.
- W1993268085 hasRelatedWork W1493948171 @default.
- W1993268085 hasRelatedWork W1989501090 @default.
- W1993268085 hasRelatedWork W1993268085 @default.
- W1993268085 hasRelatedWork W2012232448 @default.
- W1993268085 hasRelatedWork W2012749892 @default.
- W1993268085 hasRelatedWork W2051235129 @default.
- W1993268085 hasRelatedWork W2090503116 @default.
- W1993268085 hasRelatedWork W2093283271 @default.
- W1993268085 hasRelatedWork W2751385922 @default.
- W1993268085 hasRelatedWork W2460619405 @default.
- W1993268085 hasVolume "37" @default.
- W1993268085 isParatext "false" @default.
- W1993268085 isRetracted "false" @default.
- W1993268085 magId "1993268085" @default.
- W1993268085 workType "article" @default.