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- W1993272560 abstract "<h3>Importance</h3> Patients with oropharyngeal squamous cell carcinoma undergoing chemoradiotherapy may require percutaneous endoscopic gastrostomy (PEG) tube placement because of dehydration or significant weight loss. <h3>Objectives</h3> To determine the need for the reactive placement of a PEG tube during chemoradiotherapy for oropharyngeal cancer and to identify patient or tumor factors associated with reactively requiring the placement of a PEG tube. <h3>Design, Setting, and Participants</h3> Single-institution retrospective review of 297 patients treated with intensity-modulated radiation therapy and concurrent chemotherapy for oropharyngeal squamous cell carcinoma between May 1, 2004, and June 30, 2012, with a minimum follow-up period of 3 months. <h3>Exposure</h3> Placement of a PEG tube. <h3>Main Outcomes and Measures</h3> Logistic regression analysis was used to identify independent risk factors associated with symptomatic requirement for the reactive placement of a PEG tube. <h3>Results</h3> In total, 128 patients did not receive a prophylactic PEG tube within 10 days of initiation of chemoradiotherapy. Fifteen of 128 patients (11.7%) required the reactive placement of a PEG tube during or within 3 months of chemoradiotherapy. The median time to PEG tube removal was 3.3 months, and 14 of 15 patients had their PEG tube removed at the last follow-up analysis. Independent risk factors for PEG tube placement included the following: accelerated irradiation fractionation (odds ratio, 4.3; 95% CI, 1.1-16.5;<i>P</i> = .04), a tumor T classification of 3 or higher (odds ratio, 3.5; 95% CI, 1.0-11.9;<i>P</i> = .04), a cumulative cisplatin dose of 200 mg/m<sup>2</sup>or higher (odds ratio, 6.7; 95% CI, 1.2-36.7;<i>P</i> = .03), and a body mass index (calculated as weight in kilograms divided by height in meters squared) of less than 25 (odds ratio, 5.8; 95% CI, 1.4-23.9;<i>P</i> = .02). <h3>Conclusions and Relevance</h3> Although the overall risk is low, a body mass index of less than 25, accelerated irradiation fractionation, a tumor T classification of 3 or higher, and a cumulative cisplatin dose of 200 mg/m<sup>2</sup>or higher are associated with symptomatic need for the reactive placement of a PEG tube in patients with oropharyngeal cancer." @default.
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- W1993272560 date "2013-11-01" @default.
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- W1993272560 title "Risk Factors for Percutaneous Endoscopic Gastrostomy Tube Placement During Chemoradiotherapy for Oropharyngeal Cancer" @default.
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- W1993272560 doi "https://doi.org/10.1001/jamaoto.2013.5193" @default.
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