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• W1993277788 abstract "The cochlear microphonic (CM) can be a useful analytical tool, but many investigators may not be fully familiar with its unique properties to interpret it accurately in mouse models of hearing. The purpose of this report is to develop a model for generation of the CM in wild-type (WT) and prestin knockout mice. Data and modeling results indicate that in the majority of cases, the CM is a passive response, and in the absence of outer hair cell (OHC) damage, mice lacking amplification are expected to generate WT levels of CM for inputs less than ~30 kHz. Hence, this cochlear potential is not a useful metric to estimate changes in amplifier gain. This modeling analysis may explain much of the paradoxical data in the literature. For example, various manipulations, including the application of salicylate and activation of the crossed olivocochlear bundle, reduce the compound action potential but increase or do not change the CM. Based on this current evaluation, CM measurements are consistent with early descriptions where this AC cochlear potential is dominated by basal OHCs, when recorded at the round window." @default.
• W1993277788 created "2016-06-24" @default.
• W1993277788 creator A5067291970 @default.
• W1993277788 creator A5073987338 @default.
• W1993277788 creator A5081670215 @default.
• W1993277788 date "2010-10-19" @default.
• W1993277788 modified "2023-10-15" @default.
• W1993277788 title "Using the Cochlear Microphonic as a Tool to Evaluate Cochlear Function in Mouse Models of Hearing" @default.
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• W1993277788 doi "https://doi.org/10.1007/s10162-010-0240-5" @default.
• W1993277788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3015034" @default.
• W1993277788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20957507" @default.
• W1993277788 hasPublicationYear "2010" @default.
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