FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993286543> ?p ?o ?g. }

• W1993286543 endingPage "278" @default.
• W1993286543 startingPage "265" @default.
• W1993286543 abstract "Due to the large variability in survival times between cancer patients and the plethora of genes on microarrays unrelated to outcome, building accurate prediction models that are easy to interpret remains a challenge. In this paper, we propose a general strategy for improving performance and interpretability of prediction models by integrating gene expression data with prior biological knowledge. First, we link gene identifiers in expression dataset with gene annotation databases such as Gene Ontology (GO). Then we construct “supergenes” for each gene category by summarizing information from genes related to outcome using a modified principal component analysis (PCA) method. Finally, instead of using genes as predictors, we use these supergenes representing information from each gene category as predictors to predict survival outcome. In addition to identifying gene categories associated with outcome, the proposed approach also carries out additional within-category selection to select important genes within each gene set. We show, using two real breast cancer microarray datasets, that the prediction models constructed based on gene sets (or pathway) information outperform the prediction models based on expression values of single genes, with improved prediction accuracy and interpretability." @default.
• W1993286543 created "2016-06-24" @default.
• W1993286543 creator A5008171524 @default.
• W1993286543 creator A5020503630 @default.
• W1993286543 date "2009-02-01" @default.
• W1993286543 modified "2023-09-27" @default.
• W1993286543 title "Integrating Biological Knowledge with Gene Expression Profiles for Survival Prediction of Cancer" @default.
• W1993286543 cites W1560884019 @default.
• W1993286543 cites W1607267312 @default.
• W1993286543 cites W1976564639 @default.
• W1993286543 cites W1978283989 @default.
• W1993286543 cites W1979141644 @default.
• W1993286543 cites W1993528080 @default.
• W1993286543 cites W2000771269 @default.
• W1993286543 cites W2018116321 @default.
• W1993286543 cites W2019176983 @default.
• W1993286543 cites W2031832827 @default.
• W1993286543 cites W2064208261 @default.
• W1993286543 cites W2067391852 @default.
• W1993286543 cites W2071949631 @default.
• W1993286543 cites W2088160256 @default.
• W1993286543 cites W2092868756 @default.
• W1993286543 cites W2097255042 @default.
• W1993286543 cites W2097664282 @default.
• W1993286543 cites W2098421151 @default.
• W1993286543 cites W2101095383 @default.
• W1993286543 cites W2103017472 @default.
• W1993286543 cites W2108728387 @default.
• W1993286543 cites W2109044536 @default.
• W1993286543 cites W2109363337 @default.
• W1993286543 cites W2121111814 @default.
• W1993286543 cites W2123106337 @default.
• W1993286543 cites W2123664981 @default.
• W1993286543 cites W2123672572 @default.
• W1993286543 cites W2127053639 @default.
• W1993286543 cites W2128985829 @default.
• W1993286543 cites W2129895818 @default.
• W1993286543 cites W2130410032 @default.
• W1993286543 cites W2130598050 @default.
• W1993286543 cites W2134752341 @default.
• W1993286543 cites W2147246240 @default.
• W1993286543 cites W2149199519 @default.
• W1993286543 cites W2152325091 @default.
• W1993286543 cites W2154947819 @default.
• W1993286543 cites W2158497151 @default.
• W1993286543 cites W2165776880 @default.
• W1993286543 cites W2167835846 @default.
• W1993286543 cites W2168026694 @default.
• W1993286543 doi "https://doi.org/10.1089/cmb.2008.12tt" @default.
• W1993286543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3198940" @default.
• W1993286543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19183004" @default.
• W1993286543 hasPublicationYear "2009" @default.
• W1993286543 type Work @default.
• W1993286543 sameAs 1993286543 @default.
• W1993286543 citedByCount "50" @default.
• W1993286543 countsByYear W19932865432012 @default.
• W1993286543 countsByYear W19932865432013 @default.
• W1993286543 countsByYear W19932865432014 @default.
• W1993286543 countsByYear W19932865432015 @default.
• W1993286543 countsByYear W19932865432016 @default.
• W1993286543 countsByYear W19932865432017 @default.
• W1993286543 countsByYear W19932865432019 @default.
• W1993286543 countsByYear W19932865432020 @default.
• W1993286543 countsByYear W19932865432021 @default.
• W1993286543 countsByYear W19932865432023 @default.
• W1993286543 crossrefType "journal-article" @default.
• W1993286543 hasAuthorship W1993286543A5008171524 @default.
• W1993286543 hasAuthorship W1993286543A5020503630 @default.
• W1993286543 hasBestOaLocation W19932865432 @default.
• W1993286543 hasConcept C104317684 @default.
• W1993286543 hasConcept C119857082 @default.
• W1993286543 hasConcept C124101348 @default.
• W1993286543 hasConcept C144237770 @default.
• W1993286543 hasConcept C148220186 @default.
• W1993286543 hasConcept C150194340 @default.
• W1993286543 hasConcept C2781067378 @default.
• W1993286543 hasConcept C33923547 @default.
• W1993286543 hasConcept C41008148 @default.
• W1993286543 hasConcept C54355233 @default.
• W1993286543 hasConcept C60644358 @default.
• W1993286543 hasConcept C70721500 @default.
• W1993286543 hasConcept C8415881 @default.
• W1993286543 hasConcept C86803240 @default.
• W1993286543 hasConcept C95371953 @default.
• W1993286543 hasConceptScore W1993286543C104317684 @default.
• W1993286543 hasConceptScore W1993286543C119857082 @default.
• W1993286543 hasConceptScore W1993286543C124101348 @default.
• W1993286543 hasConceptScore W1993286543C144237770 @default.
• W1993286543 hasConceptScore W1993286543C148220186 @default.
• W1993286543 hasConceptScore W1993286543C150194340 @default.
• W1993286543 hasConceptScore W1993286543C2781067378 @default.
• W1993286543 hasConceptScore W1993286543C33923547 @default.
• W1993286543 hasConceptScore W1993286543C41008148 @default.
• W1993286543 hasConceptScore W1993286543C54355233 @default.
• W1993286543 hasConceptScore W1993286543C60644358 @default.
• W1993286543 hasConceptScore W1993286543C70721500 @default.
• W1993286543 hasConceptScore W1993286543C8415881 @default.
• W1993286543 hasConceptScore W1993286543C86803240 @default.

• next