FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993291250> ?p ?o ?g. }

• W1993291250 endingPage "383" @default.
• W1993291250 startingPage "377" @default.
• W1993291250 abstract "Plasmodium vivax is the most prevalent malaria species in Brazil. The parasite-host coevolutionary process can be viewed as an ‘arms race’, in which adaptive genetic changes in one are eventually matched by alterations in the other. Following the candidate gene approach we analyzed the CD40, CD40L and BLYS genes that participate in B-cell co-stimulation, for associations with P. vivax malaria. The study sample included 97 patients and 103 controls. We extracted DNA using the extraction and purification commercial kit and identified the following SNPs: −1C > T in the CD40 gene, −726T > C in the CD40L gene and the −871C > T in the BLyS gene using PCR-RFLP. We analyzed the genotype and allele frequencies by direct counting. We also compared the observed with the expected genotype frequencies using the Hardy-Weinberg equilibrium. The allele and genotype frequencies for these SNPs did not differ statistically between patient and control groups. Gene-gene interactions were not observed between the CD40 and BLYS and between the CD40L and BLYS genes. Overall, the genes were in Hardy-Weinberg equilibrium. Significant differences were not observed among the frequencies of antibody responses against P. vivax sporozoite and erythrocytic antigens and the CD40 and BLYS genotypes. The results of this study show that, although the investigated CD40, CD40L and BLYS alleles differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere in susceptibility to the disease. The variants of these genes may influence the clinical course rather than simply increase or decrease susceptibility." @default.
• W1993291250 created "2016-06-24" @default.
• W1993291250 creator A5034055041 @default.
• W1993291250 creator A5035431735 @default.
• W1993291250 creator A5036419309 @default.
• W1993291250 creator A5037758819 @default.
• W1993291250 creator A5040238285 @default.
• W1993291250 creator A5042790584 @default.
• W1993291250 creator A5053296346 @default.
• W1993291250 creator A5056134434 @default.
• W1993291250 creator A5058968127 @default.
• W1993291250 creator A5067632637 @default.
• W1993291250 creator A5077368698 @default.
• W1993291250 date "2013-04-19" @default.
• W1993291250 modified "2023-10-12" @default.
• W1993291250 title "No evidence for association of the CD40, CD40L and BLYS polymorphisms, B-cell co-stimulatory molecules, with Brazilian endemic Plasmodium vivax malaria" @default.
• W1993291250 cites W111421889 @default.
• W1993291250 cites W1625166229 @default.
• W1993291250 cites W1795608124 @default.
• W1993291250 cites W1966927617 @default.
• W1993291250 cites W1967512391 @default.
• W1993291250 cites W1971232870 @default.
• W1993291250 cites W1987576255 @default.
• W1993291250 cites W1987968095 @default.
• W1993291250 cites W2039302777 @default.
• W1993291250 cites W2039867201 @default.
• W1993291250 cites W2040890202 @default.
• W1993291250 cites W2055338105 @default.
• W1993291250 cites W2063026040 @default.
• W1993291250 cites W2079235989 @default.
• W1993291250 cites W2084180944 @default.
• W1993291250 cites W2088304428 @default.
• W1993291250 cites W2093509026 @default.
• W1993291250 cites W2112162063 @default.
• W1993291250 cites W2138295263 @default.
• W1993291250 cites W2143759641 @default.
• W1993291250 cites W2165981082 @default.
• W1993291250 cites W2166067744 @default.
• W1993291250 cites W2171640438 @default.
• W1993291250 cites W2403302911 @default.
• W1993291250 doi "https://doi.org/10.1093/trstmh/trt031" @default.
• W1993291250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23604864" @default.
• W1993291250 hasPublicationYear "2013" @default.
• W1993291250 type Work @default.
• W1993291250 sameAs 1993291250 @default.
• W1993291250 citedByCount "8" @default.
• W1993291250 countsByYear W19932912502014 @default.
• W1993291250 countsByYear W19932912502015 @default.
• W1993291250 countsByYear W19932912502016 @default.
• W1993291250 countsByYear W19932912502017 @default.
• W1993291250 countsByYear W19932912502018 @default.
• W1993291250 countsByYear W19932912502019 @default.
• W1993291250 crossrefType "journal-article" @default.
• W1993291250 hasAuthorship W1993291250A5034055041 @default.
• W1993291250 hasAuthorship W1993291250A5035431735 @default.
• W1993291250 hasAuthorship W1993291250A5036419309 @default.
• W1993291250 hasAuthorship W1993291250A5037758819 @default.
• W1993291250 hasAuthorship W1993291250A5040238285 @default.
• W1993291250 hasAuthorship W1993291250A5042790584 @default.
• W1993291250 hasAuthorship W1993291250A5053296346 @default.
• W1993291250 hasAuthorship W1993291250A5056134434 @default.
• W1993291250 hasAuthorship W1993291250A5058968127 @default.
• W1993291250 hasAuthorship W1993291250A5067632637 @default.
• W1993291250 hasAuthorship W1993291250A5077368698 @default.
• W1993291250 hasConcept C104317684 @default.
• W1993291250 hasConcept C135763542 @default.
• W1993291250 hasConcept C153209595 @default.
• W1993291250 hasConcept C159047783 @default.
• W1993291250 hasConcept C159654299 @default.
• W1993291250 hasConcept C170286685 @default.
• W1993291250 hasConcept C175239580 @default.
• W1993291250 hasConcept C180754005 @default.
• W1993291250 hasConcept C203014093 @default.
• W1993291250 hasConcept C2778048844 @default.
• W1993291250 hasConcept C2778371730 @default.
• W1993291250 hasConcept C2778453870 @default.
• W1993291250 hasConcept C2779997623 @default.
• W1993291250 hasConcept C37463918 @default.
• W1993291250 hasConcept C54355233 @default.
• W1993291250 hasConcept C69991583 @default.
• W1993291250 hasConcept C86803240 @default.
• W1993291250 hasConceptScore W1993291250C104317684 @default.
• W1993291250 hasConceptScore W1993291250C135763542 @default.
• W1993291250 hasConceptScore W1993291250C153209595 @default.
• W1993291250 hasConceptScore W1993291250C159047783 @default.
• W1993291250 hasConceptScore W1993291250C159654299 @default.
• W1993291250 hasConceptScore W1993291250C170286685 @default.
• W1993291250 hasConceptScore W1993291250C175239580 @default.
• W1993291250 hasConceptScore W1993291250C180754005 @default.
• W1993291250 hasConceptScore W1993291250C203014093 @default.
• W1993291250 hasConceptScore W1993291250C2778048844 @default.
• W1993291250 hasConceptScore W1993291250C2778371730 @default.
• W1993291250 hasConceptScore W1993291250C2778453870 @default.
• W1993291250 hasConceptScore W1993291250C2779997623 @default.
• W1993291250 hasConceptScore W1993291250C37463918 @default.
• W1993291250 hasConceptScore W1993291250C54355233 @default.
• W1993291250 hasConceptScore W1993291250C69991583 @default.
• W1993291250 hasConceptScore W1993291250C86803240 @default.

• next