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- W1993291298 abstract "The neuronal microtubule-associated protein known as MAP-2 has not been considered to be a subunit of paired helical filaments (PHFs) in neurofibrillary tangles seen in Alzheimer's Disease. We now describe the assembly of paired helical filament-like structures from MAP-2’s 203-residue microtubule-binding region (MTBR). SDS gel electrophoresis and equilibrium ultracentrifugation suggest that a dimeric form, cross-linked by an interchain disulfide, is involved in polymerization. MAP-2 MTBR polymers bind thioflavin-S, a dye used to histochemically localize Alzheimer neurofibrillary tangles. Our finding that PHF-like structures assemble from a MAP-2 fragment raises new questions about MAP-2’s role in the etiology of Alzheimer's Disease." @default.
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- W1993291298 date "1996-12-01" @default.
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- W1993291298 title "Self-Assembly of the Brain MAP-2 Microtubule-Binding Region into Polymeric Structures Resembling Alzheimer Filaments" @default.
- W1993291298 doi "https://doi.org/10.1006/bbrc.1996.1776" @default.
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