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• W1993292953 startingPage "327" @default.
• W1993292953 abstract "Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remains controversial. Here, KAR agonists are shown to enhance fiber excitability, and a number of experiments show that this is a direct effect of KARs on the presynaptic fibers. In addition, KAR activation inhibits evoked transmitter release from mossy fiber synapses. Synaptic release of glutamate from either neighboring mossy fiber synapses or associational/commisural (A/C) synapses results in the activation of these presynaptic ionotropic KARs. These results, along with previous studies, indicate that KARs, through the endogenous release of glutamate, mediate excitatory postsynaptic potentials (EPSPs), alter presynaptic excitability, and modulate transmitter release." @default.
• W1993292953 created "2016-06-24" @default.
• W1993292953 creator A5053859273 @default.
• W1993292953 creator A5061676703 @default.
• W1993292953 creator A5090979518 @default.
• W1993292953 date "2000-08-01" @default.
• W1993292953 modified "2023-10-12" @default.
• W1993292953 title "Synaptic Activation of Presynaptic Kainate Receptors on Hippocampal Mossy Fiber Synapses" @default.
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• W1993292953 doi "https://doi.org/10.1016/s0896-6273(00)00040-4" @default.
• W1993292953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10985352" @default.
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