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- W1993313171 abstract "Summary Salmonella translocate a group of type III effectors into the host cells to induce entry, promote survival and cause intestinal inflammation. Although the biochemical and cellular mechanisms of how bacterial effectors function inside host cells remain largely unknown, studies have indicated that a likely strategy is to exploit host cellular pathways through functional mimicry. We report here that SopA, a Salmonella type III effector, mimics the mammalian HECT E3 ubiquitin ligase. SopA preferentially uses the host UbcH5a, UbcH5c and UbcH7 as E2s, which are involved in inflammation. Both the wild‐type SopA and the mutant SopA C753S were expressed and translocated at similar levels during the infection of HeLa cells. A Salmonella strain expressing a catalytically incompetent SopA C753S mutant had reduced Salmonella ‐induced polymorphonuclear leukocytes transepithelial migration. We speculate that SopA ubiquitinate bacterial/host proteins involved in Salmonella ‐induced intestinal inflammation." @default.
- W1993313171 created "2016-06-24" @default.
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- W1993313171 date "2006-09-25" @default.
- W1993313171 modified "2023-10-15" @default.
- W1993313171 title "The inflammation‐associated <i>Salmonella</i> SopA is a HECT‐like E3 ubiquitin ligase" @default.
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- W1993313171 doi "https://doi.org/10.1111/j.1365-2958.2006.05407.x" @default.
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