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• W1993313182 abstract "Previous case-control studies have suggested that the -1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis.Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed.The meta-analysis of the -1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The -1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08-1.45, p = 0.004). There was heterogeneity among the 12 studies (I2 = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD." @default.
• W1993313182 created "2016-06-24" @default.
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• W1993313182 date "2013-01-01" @default.
• W1993313182 modified "2023-10-16" @default.
• W1993313182 title "Meta-Analysis of <b><i>MMP9</i></b> –1562C/T and the Risk of Coronary Heart Disease" @default.
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• W1993313182 doi "https://doi.org/10.1159/000345772" @default.
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