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- W1993313188 abstract "Abstract The effects of the administration of L-carnitine or coenzyme A (Co A) on valproic acid (VPA)-induced teratogenesis were examined in mice. VPA (300, 400, 500, 600, and 700 mg/kg, s. c.), L-carnitine (100, 200, and 400 mg/kg, s. c.), or Co A (10, 100, 200 mg/kg, i. v.) was injected on day 8 of gestation (plug day = day 0). Exencephaly was induced dose-dependently by single injections of VPA. Administration of L-carnitine or Co A alone at any of the dose levels tested did not induce embryocidal or teratogenic effects. In combined treatment experiments, L-carnitine (400 mg/kg) significantly reduced VPA (500 and 600 mg/kg)-induced exencephaly, while L-carnitine did not decrease VPA-induced open eyelids. Co A (200 mg/kg) also significantly reduced VPA-(600 mg/kg) induced exencephaly. The results demonstrate the attenuation of VPA teratogenicity by L-carnitine and Co A." @default.
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- W1993313188 date "1996-06-01" @default.
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- W1993313188 title "Carnitine and Coenzyme A Decrease Valproic Acid-Induced Neural Tube Defects in Mice" @default.
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- W1993313188 doi "https://doi.org/10.1111/j.1741-4520.1996.tb00622.x" @default.
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