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- W1993314807 abstract "Abstract Heparanase is an endo‐β‐ d ‐glucuronidase which specifically cleaves extracellular and cell surface heparan sulphates at intra‐chain sites. Its enzymatic activity is strongly implicated in cell dissemination associated with tumor metastasis and inflammation. Indeed, heparanase gene is expressed in various tumors and its over‐expression is correlated with increased tumor vascularity and metastatic potential of tumor cells. However, heparanase expression in non‐invasive and non‐immune tissue, including brain, has received less attention. Using RT‐qPCR, western blot and histological analysis, we demonstrate in the adult rat that heparanase transcript is differentially expressed according to brain area, and that heparanase protein is mainly detected in neurons. Furthermore, we provide evidence that heparanase transcript and protein reach their greatest levels at early postnatal stages, in particular within the neocortex characterized by intensive structural plasticity. Using the in vitro model of PC12‐induced neuronal differentiation, we suggest that developmental regulation of heparanase may coincide with axonal and dendritic pathfinding. At adulthood, we demonstrate that the increased heparanase transcript level correlates in the hippocampus with enhanced angiogenesis following repeated hypoxia exposures. Taken together, our results emphasize the potential importance of heparanase in brain homeostasis, both during development and adaptative responses to severe environmental challenges." @default.
- W1993314807 created "2016-06-24" @default.
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- W1993314807 date "2007-11-07" @default.
- W1993314807 modified "2023-10-02" @default.
- W1993314807 title "Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats" @default.
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- W1993314807 cites W1969962851 @default.
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- W1993314807 cites W1977576363 @default.
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- W1993314807 cites W1980147688 @default.
- W1993314807 cites W1982098988 @default.
- W1993314807 cites W1987216810 @default.
- W1993314807 cites W1989676517 @default.
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- W1993314807 cites W2004577947 @default.
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- W1993314807 cites W2006641366 @default.
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- W1993314807 cites W2076100222 @default.
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- W1993314807 doi "https://doi.org/10.1111/j.1471-4159.2007.05116.x" @default.
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