Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993317963> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1993317963 abstract "The glutamate hypothesis of schizophrenia based on the observations that administration of drugs that block N-methyl-D-aspartate (NMDA) glutamate receptors could induce schizophrenia-like symptoms. There are several evidences linking abnormal glutamatergic transmission to cognitive, negative, and positive symptoms of schizophrenia and the glutamatergic system is now a major focus for the development of new compounds in schizophrenia.The polyamines are omnipresent aliphatic molecules comprising putrescine, spermidine, spermine and agmatine. The polyamines and their biosynthetic enzymes are found throughout the body, including the central nervous system (CNS), where they display specific regional distributions in the CNS. The polyamines have an important role in the modulation of cell growth and on cell membrane functions. It was hypothesized that schizophrenia may be related to a general abnormality in neuronal membranes. Agmatine, a polyamine, selectively blocks the NMDA subclass of glutamate receptors in rat hippocampal neurons. There are several evidence indicate that a relationship between polyamines and etiopatogenezis of schizophrenia. Here, in this rewiev, a new approach for understanding schizophrenia via NMDA receptors and their interaction with agmatine which is a biological active polyamine transmitter in brain is proposed." @default.
- W1993317963 created "2016-06-24" @default.
- W1993317963 creator A5071431302 @default.
- W1993317963 date "2014-01-01" @default.
- W1993317963 modified "2023-09-27" @default.
- W1993317963 title "An alternative approach to understand schizophrenia: polyamines hypothesis through NMDA receptors" @default.
- W1993317963 doi "https://doi.org/10.5455/jnbs.1406279771" @default.
- W1993317963 hasPublicationYear "2014" @default.
- W1993317963 type Work @default.
- W1993317963 sameAs 1993317963 @default.
- W1993317963 citedByCount "0" @default.
- W1993317963 crossrefType "journal-article" @default.
- W1993317963 hasAuthorship W1993317963A5071431302 @default.
- W1993317963 hasConcept C169760540 @default.
- W1993317963 hasConcept C170493617 @default.
- W1993317963 hasConcept C181199279 @default.
- W1993317963 hasConcept C185592680 @default.
- W1993317963 hasConcept C2776109719 @default.
- W1993317963 hasConcept C2777167505 @default.
- W1993317963 hasConcept C2777497464 @default.
- W1993317963 hasConcept C2780115381 @default.
- W1993317963 hasConcept C2780376555 @default.
- W1993317963 hasConcept C2780648746 @default.
- W1993317963 hasConcept C2781448169 @default.
- W1993317963 hasConcept C55493867 @default.
- W1993317963 hasConcept C61174792 @default.
- W1993317963 hasConcept C67018056 @default.
- W1993317963 hasConcept C86803240 @default.
- W1993317963 hasConcept C98274493 @default.
- W1993317963 hasConceptScore W1993317963C169760540 @default.
- W1993317963 hasConceptScore W1993317963C170493617 @default.
- W1993317963 hasConceptScore W1993317963C181199279 @default.
- W1993317963 hasConceptScore W1993317963C185592680 @default.
- W1993317963 hasConceptScore W1993317963C2776109719 @default.
- W1993317963 hasConceptScore W1993317963C2777167505 @default.
- W1993317963 hasConceptScore W1993317963C2777497464 @default.
- W1993317963 hasConceptScore W1993317963C2780115381 @default.
- W1993317963 hasConceptScore W1993317963C2780376555 @default.
- W1993317963 hasConceptScore W1993317963C2780648746 @default.
- W1993317963 hasConceptScore W1993317963C2781448169 @default.
- W1993317963 hasConceptScore W1993317963C55493867 @default.
- W1993317963 hasConceptScore W1993317963C61174792 @default.
- W1993317963 hasConceptScore W1993317963C67018056 @default.
- W1993317963 hasConceptScore W1993317963C86803240 @default.
- W1993317963 hasConceptScore W1993317963C98274493 @default.
- W1993317963 hasLocation W19933179631 @default.
- W1993317963 hasOpenAccess W1993317963 @default.
- W1993317963 hasPrimaryLocation W19933179631 @default.
- W1993317963 hasRelatedWork W118160622 @default.
- W1993317963 hasRelatedWork W1507804974 @default.
- W1993317963 hasRelatedWork W1924382915 @default.
- W1993317963 hasRelatedWork W1991711702 @default.
- W1993317963 hasRelatedWork W2002653194 @default.
- W1993317963 hasRelatedWork W2012911948 @default.
- W1993317963 hasRelatedWork W2024330927 @default.
- W1993317963 hasRelatedWork W2028789739 @default.
- W1993317963 hasRelatedWork W2056092101 @default.
- W1993317963 hasRelatedWork W206219436 @default.
- W1993317963 hasRelatedWork W2083603806 @default.
- W1993317963 hasRelatedWork W2093539065 @default.
- W1993317963 hasRelatedWork W2097323497 @default.
- W1993317963 hasRelatedWork W2097693079 @default.
- W1993317963 hasRelatedWork W2166092131 @default.
- W1993317963 hasRelatedWork W2292662545 @default.
- W1993317963 hasRelatedWork W2414711604 @default.
- W1993317963 hasRelatedWork W2418323295 @default.
- W1993317963 hasRelatedWork W2899845673 @default.
- W1993317963 hasRelatedWork W3112187122 @default.
- W1993317963 isParatext "false" @default.
- W1993317963 isRetracted "false" @default.
- W1993317963 magId "1993317963" @default.
- W1993317963 workType "article" @default.