Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993320011> ?p ?o ?g. }
- W1993320011 endingPage "127" @default.
- W1993320011 startingPage "119" @default.
- W1993320011 abstract "It has been demonstrated in vitro that lipoprotein(a) [Lp(a)] increases the endothelial synthesis of plasminogen activator inhibitor 1 (PAI-1). However, this effect in vivo is controversial, and the possible relationship between PAI-1 and Lp(a) phenotypes has not been evaluated. The aim of the study was to determine the influence of Lp(a) and its phenotypes on PAI-1 serum concentrations in diabetic patients. For this purpose we include 75 Caucasian diabetic patients (34 consecutive type I and 41 consecutive type II) without late diabetic complications. Lp(a) and PAI-1 were assessed by ELISA. Lp(a) phenotypes were determined by SDS-PAGE followed by immunoblotting, and grouped according to size in small (F,B,S1,S2), big (S3,S4), and null. A linear correlation between Lp(a) and PAI-1 was not observed either as a whole or when type I and type II diabetic patients were analyzed separately. However, significant differences were detected in PAI-1 levels when Lp(a) phenotypes were considered (small: 42.1+/-31.8 ng/mL; big: 37.2+/-26.1 ng/mL; null: 14.4+/-14.4; p< 0.05). The significant differences were due to the low PAI-1 concentrations observed in patients with null phenotype. Our results suggest that fibrinolytic activity might be preserved in diabetic patients with null Lp(a) phenotype. Furthermore, it could be speculated that diabetic patients with null phenotype should be considered at low risk to develop cardiovascular disease." @default.
- W1993320011 created "2016-06-24" @default.
- W1993320011 creator A5017014718 @default.
- W1993320011 creator A5028069832 @default.
- W1993320011 creator A5069144847 @default.
- W1993320011 creator A5090539652 @default.
- W1993320011 creator A5091908088 @default.
- W1993320011 date "2000-07-01" @default.
- W1993320011 modified "2023-09-27" @default.
- W1993320011 title "Relationship Between Lipoprotein(a) Phenotypes and Plaminogen Activator Inhibitor Type 1 in Diabetic Patients" @default.
- W1993320011 cites W147868144 @default.
- W1993320011 cites W1559817730 @default.
- W1993320011 cites W1588845829 @default.
- W1993320011 cites W1963792702 @default.
- W1993320011 cites W1964663754 @default.
- W1993320011 cites W1969230739 @default.
- W1993320011 cites W1970518565 @default.
- W1993320011 cites W1972440424 @default.
- W1993320011 cites W1973848654 @default.
- W1993320011 cites W1977726586 @default.
- W1993320011 cites W1978031144 @default.
- W1993320011 cites W1979402100 @default.
- W1993320011 cites W1986030167 @default.
- W1993320011 cites W1990593445 @default.
- W1993320011 cites W1990768246 @default.
- W1993320011 cites W1992421645 @default.
- W1993320011 cites W1993115785 @default.
- W1993320011 cites W1999863674 @default.
- W1993320011 cites W2002146594 @default.
- W1993320011 cites W2010782167 @default.
- W1993320011 cites W2010933740 @default.
- W1993320011 cites W2011217377 @default.
- W1993320011 cites W2019849071 @default.
- W1993320011 cites W2031510621 @default.
- W1993320011 cites W2032242304 @default.
- W1993320011 cites W2032430567 @default.
- W1993320011 cites W2035614767 @default.
- W1993320011 cites W2036170644 @default.
- W1993320011 cites W2039831544 @default.
- W1993320011 cites W2041232313 @default.
- W1993320011 cites W2042148803 @default.
- W1993320011 cites W2043951336 @default.
- W1993320011 cites W2050032102 @default.
- W1993320011 cites W2052249127 @default.
- W1993320011 cites W2055337593 @default.
- W1993320011 cites W2059569088 @default.
- W1993320011 cites W2078703458 @default.
- W1993320011 cites W2079301756 @default.
- W1993320011 cites W2085087376 @default.
- W1993320011 cites W2091066652 @default.
- W1993320011 cites W2092362047 @default.
- W1993320011 cites W2100369738 @default.
- W1993320011 cites W2115112300 @default.
- W1993320011 cites W2129006332 @default.
- W1993320011 cites W2136145860 @default.
- W1993320011 cites W2160770343 @default.
- W1993320011 cites W2281293425 @default.
- W1993320011 cites W2414440707 @default.
- W1993320011 cites W4229808731 @default.
- W1993320011 cites W4233118541 @default.
- W1993320011 cites W4240118395 @default.
- W1993320011 cites W4243810418 @default.
- W1993320011 cites W4244633958 @default.
- W1993320011 cites W4245809230 @default.
- W1993320011 doi "https://doi.org/10.1016/s0049-3848(00)00248-6" @default.
- W1993320011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10946085" @default.
- W1993320011 hasPublicationYear "2000" @default.
- W1993320011 type Work @default.
- W1993320011 sameAs 1993320011 @default.
- W1993320011 citedByCount "14" @default.
- W1993320011 countsByYear W19933200112014 @default.
- W1993320011 countsByYear W19933200112016 @default.
- W1993320011 countsByYear W19933200112021 @default.
- W1993320011 crossrefType "journal-article" @default.
- W1993320011 hasAuthorship W1993320011A5017014718 @default.
- W1993320011 hasAuthorship W1993320011A5028069832 @default.
- W1993320011 hasAuthorship W1993320011A5069144847 @default.
- W1993320011 hasAuthorship W1993320011A5090539652 @default.
- W1993320011 hasAuthorship W1993320011A5091908088 @default.
- W1993320011 hasConcept C104317684 @default.
- W1993320011 hasConcept C126322002 @default.
- W1993320011 hasConcept C127716648 @default.
- W1993320011 hasConcept C134018914 @default.
- W1993320011 hasConcept C207001950 @default.
- W1993320011 hasConcept C2776104379 @default.
- W1993320011 hasConcept C2777180221 @default.
- W1993320011 hasConcept C2778163477 @default.
- W1993320011 hasConcept C2779679481 @default.
- W1993320011 hasConcept C2780072125 @default.
- W1993320011 hasConcept C2780675426 @default.
- W1993320011 hasConcept C2909373784 @default.
- W1993320011 hasConcept C54355233 @default.
- W1993320011 hasConcept C555293320 @default.
- W1993320011 hasConcept C71924100 @default.
- W1993320011 hasConcept C86803240 @default.
- W1993320011 hasConceptScore W1993320011C104317684 @default.
- W1993320011 hasConceptScore W1993320011C126322002 @default.
- W1993320011 hasConceptScore W1993320011C127716648 @default.