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• W1993328343 abstract "Elite controllers or suppressors (ES) are HIV-1-infected individuals who suppress viral replication to clinically undetectable levels without antiretroviral therapy. Understanding the mechanisms by which ES control viral replication may prove informative for the design of a therapeutic vaccine. Qualitative differences in the CD8(+) T cell response have been implicated in control. Therefore, we isolated CD8(+) T cells from ES and characterized the ability of sorted memory and activation subpopulations to control viral replication at various effector-to-target cell ratios using a novel modification of a CD8(+) T cell suppression assay. The effector memory and terminal effector subpopulations of memory CD8(+) T cells had the highest inhibitory potential over the course of a 3-day in vitro infection. Interestingly, after 5 days of infection, central memory CD8(+) T cells were also very effective at suppressing viral replication. No significant correlation between the suppression of viral replication and the number of HIV-1-specific CD8(+) T cells was observed. HLA-DR(-) CD38(+) CD8(+) T cells possessed the lowest inhibitory potential of the activation subpopulations. Taken together, our data suggest that there are key differences in the magnitude and kinetics of the suppression of HIV-1 replication by different CD8(+) T cell subsets. These data should guide the development of an effective, cellular therapeutic vaccine that has the potential to elicit similar CD8(+) T cell responses." @default.
• W1993328343 created "2016-06-24" @default.
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• W1993328343 date "2012-12-15" @default.
• W1993328343 modified "2023-09-26" @default.
• W1993328343 title "Inhibitory Potential of Subpopulations of CD8⁺T Cells in HIV-1-Infected Elite Suppressors" @default.
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• W1993328343 doi "https://doi.org/10.1128/jvi.02439-12" @default.
• W1993328343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3503034" @default.
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