Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993336124> ?p ?o ?g. }
- W1993336124 endingPage "119" @default.
- W1993336124 startingPage "110" @default.
- W1993336124 abstract "Oxidative stress, a process in which neurotoxic oxygen free radicals cause dopaminergic neuronal degeneration, has been implicated in the degenerative process in Parkinson's disease. Glutamate-induced neurotoxicity is a model of oxidative stress. We demonstrated that preincubation with D2-type dopamine agonists bromocriptine and quinpirole provides neuroprotection against glutamate-induced neurotoxicity in cultured rat mesencephalic neurons. Simultaneous administration of D2 agonists, however, did not provide neuroprotection. The protective effects were dependent on the duration of preincubation and were blocked by a D2 antagonist and a protein synthesis inhibitor. Furthermore, preincubation with D2 agonists provided neuroprotection against toxicity induced by calcium overload and exposure to superoxide anions. Confocal microscopic analysis, using 2,7-dichlorofluorescin diacetate, revealed that bromocriptine preincubation suppressed the action of radicals on neurons. These findings indicate that dopamine D2 agonists provide protection mediated not only by the inhibition of dopamine turnover but also via D2-type dopamine receptor stimulation and the subsequent synthesis of proteins that scavenge free radicals." @default.
- W1993336124 created "2016-06-24" @default.
- W1993336124 creator A5031591186 @default.
- W1993336124 creator A5043762491 @default.
- W1993336124 creator A5047187786 @default.
- W1993336124 creator A5048153044 @default.
- W1993336124 creator A5048622717 @default.
- W1993336124 creator A5069055172 @default.
- W1993336124 creator A5088123955 @default.
- W1993336124 date "1998-07-01" @default.
- W1993336124 modified "2023-10-16" @default.
- W1993336124 title "Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress" @default.
- W1993336124 cites W1516230268 @default.
- W1993336124 cites W1531374158 @default.
- W1993336124 cites W1606988289 @default.
- W1993336124 cites W1625996387 @default.
- W1993336124 cites W1900535849 @default.
- W1993336124 cites W1966092598 @default.
- W1993336124 cites W1973473665 @default.
- W1993336124 cites W1976468205 @default.
- W1993336124 cites W1978850926 @default.
- W1993336124 cites W1994121039 @default.
- W1993336124 cites W1998670757 @default.
- W1993336124 cites W1998938785 @default.
- W1993336124 cites W2017549779 @default.
- W1993336124 cites W2017577705 @default.
- W1993336124 cites W2021066570 @default.
- W1993336124 cites W2023105087 @default.
- W1993336124 cites W2039152833 @default.
- W1993336124 cites W2039727503 @default.
- W1993336124 cites W2042162774 @default.
- W1993336124 cites W2043881516 @default.
- W1993336124 cites W2047273909 @default.
- W1993336124 cites W2047632293 @default.
- W1993336124 cites W2050636568 @default.
- W1993336124 cites W2052344768 @default.
- W1993336124 cites W2052548407 @default.
- W1993336124 cites W2052583566 @default.
- W1993336124 cites W2054731042 @default.
- W1993336124 cites W2057810394 @default.
- W1993336124 cites W2059230444 @default.
- W1993336124 cites W2062530699 @default.
- W1993336124 cites W2067968862 @default.
- W1993336124 cites W2068509668 @default.
- W1993336124 cites W2069174611 @default.
- W1993336124 cites W2076009972 @default.
- W1993336124 cites W2076070239 @default.
- W1993336124 cites W2078715709 @default.
- W1993336124 cites W2080645324 @default.
- W1993336124 cites W2084022990 @default.
- W1993336124 cites W2091097006 @default.
- W1993336124 cites W2091364830 @default.
- W1993336124 cites W2095456713 @default.
- W1993336124 cites W2126704418 @default.
- W1993336124 cites W2133451731 @default.
- W1993336124 cites W2150656456 @default.
- W1993336124 cites W2150857721 @default.
- W1993336124 cites W2156259977 @default.
- W1993336124 cites W2161688791 @default.
- W1993336124 cites W4252360861 @default.
- W1993336124 doi "https://doi.org/10.1002/ana.410440117" @default.
- W1993336124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9667598" @default.
- W1993336124 hasPublicationYear "1998" @default.
- W1993336124 type Work @default.
- W1993336124 sameAs 1993336124 @default.
- W1993336124 citedByCount "143" @default.
- W1993336124 countsByYear W19933361242012 @default.
- W1993336124 countsByYear W19933361242013 @default.
- W1993336124 countsByYear W19933361242014 @default.
- W1993336124 countsByYear W19933361242015 @default.
- W1993336124 countsByYear W19933361242016 @default.
- W1993336124 countsByYear W19933361242017 @default.
- W1993336124 countsByYear W19933361242021 @default.
- W1993336124 countsByYear W19933361242022 @default.
- W1993336124 countsByYear W19933361242023 @default.
- W1993336124 crossrefType "journal-article" @default.
- W1993336124 hasAuthorship W1993336124A5031591186 @default.
- W1993336124 hasAuthorship W1993336124A5043762491 @default.
- W1993336124 hasAuthorship W1993336124A5047187786 @default.
- W1993336124 hasAuthorship W1993336124A5048153044 @default.
- W1993336124 hasAuthorship W1993336124A5048622717 @default.
- W1993336124 hasAuthorship W1993336124A5069055172 @default.
- W1993336124 hasAuthorship W1993336124A5088123955 @default.
- W1993336124 hasConcept C126322002 @default.
- W1993336124 hasConcept C137183658 @default.
- W1993336124 hasConcept C170493617 @default.
- W1993336124 hasConcept C178790620 @default.
- W1993336124 hasConcept C185592680 @default.
- W1993336124 hasConcept C25498285 @default.
- W1993336124 hasConcept C2776151105 @default.
- W1993336124 hasConcept C2776856834 @default.
- W1993336124 hasConcept C2778296116 @default.
- W1993336124 hasConcept C2779064019 @default.
- W1993336124 hasConcept C2779491297 @default.
- W1993336124 hasConcept C29730261 @default.
- W1993336124 hasConcept C44208683 @default.
- W1993336124 hasConcept C513476851 @default.
- W1993336124 hasConcept C55493867 @default.