Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993340412> ?p ?o ?g. }
- W1993340412 endingPage "344" @default.
- W1993340412 startingPage "335" @default.
- W1993340412 abstract "Induction of hepatic stellate cell (HSC) apoptosis attenuates hepatic fibrosis, and, therefore, mechanisms to induce HSC cell death are of therapeutic interest. Proteasome inhibitors induce apoptosis in transformed cells, especially those cells dependent upon nuclear factor kappa B (NF-κB) activation. Because stimulated HSCs also trigger NF-κB activation, the aim of this study was to determine if proteasome inhibitors induce HSC apoptosis. The immortalized human HSC line, LX-2, and primary rat HSCs were treated with the proteasome inhibitors bortezomib and MG132. Both proteasome inhibitors induced HSC apoptosis. Proteasome inhibition blocked NF-κB activation and, more importantly, NF-κB inhibition by Bay11-7082–triggered HSC apoptosis. Activated HSC survival is dependent upon the NF-κB target gene A1, an anti-apoptotic Bcl-2 family member, as siRNA targeted knockdown of A1-induced HSC apoptosis. In contrast, proteasome inhibition–induced alterations in TRAIL, death receptor 5, and Bim could not be implicated in the apoptotic response. The relevance of these findings was confirmed in the bile-duct–ligated mouse where bortezomib reduced hepatic markers of stellate cell activation and fibrosis. In conclusion, proteasome inhibition is a potential therapeutic strategy for inducing HSC apoptosis and inhibiting liver fibrogenesis. (HEPATOLOGY 2006;43:335–344.)" @default.
- W1993340412 created "2016-06-24" @default.
- W1993340412 creator A5004470985 @default.
- W1993340412 creator A5041545551 @default.
- W1993340412 creator A5048615239 @default.
- W1993340412 creator A5061211549 @default.
- W1993340412 creator A5061507227 @default.
- W1993340412 creator A5081293248 @default.
- W1993340412 date "2006-01-01" @default.
- W1993340412 modified "2023-10-12" @default.
- W1993340412 title "Proteasome inhibition induces hepatic stellate cell apoptosis" @default.
- W1993340412 cites W1542326554 @default.
- W1993340412 cites W1911342746 @default.
- W1993340412 cites W1911504906 @default.
- W1993340412 cites W1975694876 @default.
- W1993340412 cites W1977911088 @default.
- W1993340412 cites W1979372049 @default.
- W1993340412 cites W1980471295 @default.
- W1993340412 cites W1983474840 @default.
- W1993340412 cites W1984077928 @default.
- W1993340412 cites W1986826310 @default.
- W1993340412 cites W1990408342 @default.
- W1993340412 cites W1991501592 @default.
- W1993340412 cites W1992584170 @default.
- W1993340412 cites W1997064567 @default.
- W1993340412 cites W2005025375 @default.
- W1993340412 cites W2008355658 @default.
- W1993340412 cites W2014617922 @default.
- W1993340412 cites W2016498524 @default.
- W1993340412 cites W2018251493 @default.
- W1993340412 cites W2034198373 @default.
- W1993340412 cites W2038990415 @default.
- W1993340412 cites W2049028404 @default.
- W1993340412 cites W2058473971 @default.
- W1993340412 cites W2080325240 @default.
- W1993340412 cites W2083410657 @default.
- W1993340412 cites W2085419794 @default.
- W1993340412 cites W2086189875 @default.
- W1993340412 cites W2105073777 @default.
- W1993340412 cites W2131358644 @default.
- W1993340412 cites W2133984207 @default.
- W1993340412 cites W2134060756 @default.
- W1993340412 cites W2134388096 @default.
- W1993340412 cites W2134497025 @default.
- W1993340412 cites W2145152689 @default.
- W1993340412 cites W2147760686 @default.
- W1993340412 cites W2149559639 @default.
- W1993340412 cites W2153496829 @default.
- W1993340412 cites W2154663821 @default.
- W1993340412 cites W2161803404 @default.
- W1993340412 cites W2165062244 @default.
- W1993340412 cites W2169295136 @default.
- W1993340412 cites W2171137321 @default.
- W1993340412 cites W2470223656 @default.
- W1993340412 cites W37351408 @default.
- W1993340412 cites W4255712601 @default.
- W1993340412 doi "https://doi.org/10.1002/hep.21036" @default.
- W1993340412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16440346" @default.
- W1993340412 hasPublicationYear "2006" @default.
- W1993340412 type Work @default.
- W1993340412 sameAs 1993340412 @default.
- W1993340412 citedByCount "122" @default.
- W1993340412 countsByYear W19933404122012 @default.
- W1993340412 countsByYear W19933404122013 @default.
- W1993340412 countsByYear W19933404122014 @default.
- W1993340412 countsByYear W19933404122015 @default.
- W1993340412 countsByYear W19933404122016 @default.
- W1993340412 countsByYear W19933404122017 @default.
- W1993340412 countsByYear W19933404122018 @default.
- W1993340412 countsByYear W19933404122019 @default.
- W1993340412 countsByYear W19933404122020 @default.
- W1993340412 countsByYear W19933404122021 @default.
- W1993340412 countsByYear W19933404122022 @default.
- W1993340412 countsByYear W19933404122023 @default.
- W1993340412 crossrefType "journal-article" @default.
- W1993340412 hasAuthorship W1993340412A5004470985 @default.
- W1993340412 hasAuthorship W1993340412A5041545551 @default.
- W1993340412 hasAuthorship W1993340412A5048615239 @default.
- W1993340412 hasAuthorship W1993340412A5061211549 @default.
- W1993340412 hasAuthorship W1993340412A5061507227 @default.
- W1993340412 hasAuthorship W1993340412A5081293248 @default.
- W1993340412 hasConcept C104317684 @default.
- W1993340412 hasConcept C123298856 @default.
- W1993340412 hasConcept C134018914 @default.
- W1993340412 hasConcept C176891718 @default.
- W1993340412 hasConcept C190283241 @default.
- W1993340412 hasConcept C203014093 @default.
- W1993340412 hasConcept C27740335 @default.
- W1993340412 hasConcept C2776364478 @default.
- W1993340412 hasConcept C2777478702 @default.
- W1993340412 hasConcept C2777730290 @default.
- W1993340412 hasConcept C2778367456 @default.
- W1993340412 hasConcept C2778506107 @default.
- W1993340412 hasConcept C31573885 @default.
- W1993340412 hasConcept C502942594 @default.
- W1993340412 hasConcept C55493867 @default.
- W1993340412 hasConcept C86339819 @default.
- W1993340412 hasConcept C86803240 @default.