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• W1993345277 abstract "<i>Background:</i> Peach is a common food allergen source throughout Europe. The aim of this study was to characterize peach allergy in a Portuguese patient population. <i>Methods:</i> Thirty peach-allergic patients confirmed by double-blind placebo-controlled food challenges and 29 controls were included. All subjects completed a standardized questionnaire regarding symptoms and epidemiologic characteristics, skin prick tests with inhalant allergens and foods as well as specific IgE antibodies to peach, recombinant peach allergens rPru p 1, rPru p 3, rPru p 4 and cross-reactive carbohydrate determinants. <i>Results:</i> Thirty-seven percent of patients reported only oral allergy syndrome, while 37% reported generalized urticaria and/or angioedema, 17% localized contact urticaria and 10% anaphylaxis with peach. Sensitization to other <i>Rosaceae</i> fruits and tree nuts was present in 90 and 77% of the patients, respectively. Respiratory allergy history was associated with less severe symptoms (oral allergy syndrome or contact urticaria; p < 0.01) and positive skin prick test to peach peel or plum with more severe symptoms (urticaria and/or angioedema or anaphylaxis; p < 0.05). Ninety-seven percent were sensitized to Pru p 3, 13% to Pru p 4, 3% to Pru p 1 and 10% to cross-reactive carbohydrate determinants. Pru p 3 specific IgE was associated with <i>Artemisia vulgaris</i> sensitization and tree nut allergy (p < 0.05) but not with clinical severity. <i>Conclusions:</i> Half the patients reported systemic reactions to peach. Peach allergy appeared predominantly mediated by Pru p 3 but some patients were sensitized to Pru p 4. Applying a 0.10 kU_A/l cutoff level, the diagnostic value of combining the 3 recombinant allergens was noteworthy, with 100% sensitivity and 90% specificity." @default.
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• W1993345277 date "2008-11-26" @default.
• W1993345277 modified "2023-09-27" @default.
• W1993345277 title "Clinical, Anamnestic and Serological Features of Peach Allergy in Portugal" @default.
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• W1993345277 doi "https://doi.org/10.1159/000176308" @default.
• W1993345277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19033734" @default.
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