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- W1993354537 abstract "Effects of acute rotational stress on the tissue distribution of lymphocyte subpopulations, and the capacity to mount a humoral immune response were examined in normal and adrenalectomized mice. The splenic lymphocyte population showed a significant alteration in its content of T lymphocytes in normal, but not adrenalectomized animals subjected to rotational stress. Thus adrenal steroids may influence lymphocyte subpopulations in animals responding to stress. Humoral immune responsiveness of splenic lymphocytes was assessed by a direct lymphocyte plaque forming cell assay following immunization with sheep erythrocytes. The peak number of lymphocytes forming antibody to sheep erythrocytes found in spleens of animals subjected to stress begun 24 hours after antigen inoculation was 50% of the number observed in animals immunized and stressed simultaneously (p less than .001). No effect of adrenalectomy on the reduction in the numbers of antibody forming lymphocytes was observed. We conclude that stress can modify immune responsiveness by a number of mechanisms, some of which are independent of adrenal corticosteroid action." @default.
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- W1993354537 date "1987-01-01" @default.
- W1993354537 modified "2023-10-18" @default.
- W1993354537 title "Stress-induced alteration of T-lymphocyte subsets and humoral immunity in mice." @default.
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- W1993354537 doi "https://doi.org/10.1037//0735-7044.101.1.115" @default.
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