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- W1993356811 abstract "The ability of some N,N-dialkylaminosubstituted chromones and isoxazoles to inhibit the protein kinase C (PKC) dependent signal transduction pathway was tested. As a cellular model, human neutrophils stimulated with either phorbol myristate acetate (PMA) or formylmethionine-leucine-phenylalanine (f-MLF) were used. The efficiency of the compounds was established by their capacity to reduce the O2- production by activated human neutrophils. Compounds carrying a 3-bis(2-methoxyethyl)amino group, a substituent found active in previously tested tricyclic compounds, do not show significant anti-PKC activity in this study. On the other hand, substitution with a 1-piperidinyl group leads all tested compounds to a high biological activity against stimulated neutrophils." @default.
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- W1993356811 date "1999-07-01" @default.
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- W1993356811 title "N,N-Dialkylaminosubstituted chromones and isoxazoles as potential anti-inflammatory agents" @default.
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- W1993356811 doi "https://doi.org/10.1016/s0014-827x(99)00051-8" @default.
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