FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993358922> ?p ?o ?g. }

• W1993358922 endingPage "386" @default.
• W1993358922 startingPage "378" @default.
• W1993358922 abstract "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a selective loss of motor neurons in the motor cortex, brainstem, and spinal cord. It has been shown that oxidative stress plays a pivotal role in the progression of this motor neuron loss. We have previously reported that L-745,870, a dopamine D4 receptor antagonist, selectively inhibits oxidative stress-induced cell death in vitro and exerts a potent neuroprotective effect against ischemia-induced neural cell damage in gerbil. To investigate the efficacy of L-745,870 in the treatment of ALS, we here conducted a chronic administration of L-745,870 to transgenic mice expressing a mutated form of human superoxide dismutase gene (SOD1(H46R)); a mouse model of familial ALS, and assessed whether the mice benefit from this treatment. The pre-onset administration of L-745,870 significantly delayed the onset of motor deficits, slowed the disease progression, and extended a life span in transgenic mice. These animals showed a delayed loss of anterior horn cells in the spinal cord concomitant with a reduced level of microglial activation at a late symptomatic stage. Further, the post-onset administration of L-745,870 to the SOD1(H46R) transgenic mice remarkably slowed the disease progression and extended their life spans. Taken together, our findings in a rodent model of ALS may have implication that L-745,870 is a possible novel therapeutic means to the treatment of ALS." @default.
• W1993358922 created "2016-06-24" @default.
• W1993358922 creator A5027520438 @default.
• W1993358922 creator A5037638547 @default.
• W1993358922 creator A5040919280 @default.
• W1993358922 creator A5042750362 @default.
• W1993358922 creator A5046487127 @default.
• W1993358922 creator A5047371947 @default.
• W1993358922 creator A5048407860 @default.
• W1993358922 creator A5049392699 @default.
• W1993358922 creator A5050470835 @default.
• W1993358922 creator A5056181653 @default.
• W1993358922 creator A5058498811 @default.
• W1993358922 creator A5073117349 @default.
• W1993358922 creator A5076840816 @default.
• W1993358922 creator A5091307002 @default.
• W1993358922 date "2008-06-01" @default.
• W1993358922 modified "2023-09-27" @default.
• W1993358922 title "A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice" @default.
• W1993358922 cites W1555605403 @default.
• W1993358922 cites W1948919957 @default.
• W1993358922 cites W1964463501 @default.
• W1993358922 cites W1970606529 @default.
• W1993358922 cites W1978885930 @default.
• W1993358922 cites W1993064034 @default.
• W1993358922 cites W1997045117 @default.
• W1993358922 cites W2002905271 @default.
• W1993358922 cites W2004349171 @default.
• W1993358922 cites W2007395718 @default.
• W1993358922 cites W2008170648 @default.
• W1993358922 cites W2013801793 @default.
• W1993358922 cites W2021374516 @default.
• W1993358922 cites W2032706712 @default.
• W1993358922 cites W2034651824 @default.
• W1993358922 cites W2042710718 @default.
• W1993358922 cites W2047022382 @default.
• W1993358922 cites W2051118048 @default.
• W1993358922 cites W2053137713 @default.
• W1993358922 cites W2071921711 @default.
• W1993358922 cites W2073864172 @default.
• W1993358922 cites W2075691498 @default.
• W1993358922 cites W2082118250 @default.
• W1993358922 cites W2087788920 @default.
• W1993358922 cites W2096386031 @default.
• W1993358922 cites W2107660300 @default.
• W1993358922 cites W2108379668 @default.
• W1993358922 cites W2111425451 @default.
• W1993358922 cites W2111483267 @default.
• W1993358922 cites W2128815118 @default.
• W1993358922 cites W2150095505 @default.
• W1993358922 cites W4248797315 @default.
• W1993358922 cites W4295887104 @default.
• W1993358922 doi "https://doi.org/10.1016/j.expneurol.2008.02.004" @default.
• W1993358922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18423451" @default.
• W1993358922 hasPublicationYear "2008" @default.
• W1993358922 type Work @default.
• W1993358922 sameAs 1993358922 @default.
• W1993358922 citedByCount "31" @default.
• W1993358922 countsByYear W19933589222012 @default.
• W1993358922 countsByYear W19933589222013 @default.
• W1993358922 countsByYear W19933589222014 @default.
• W1993358922 countsByYear W19933589222015 @default.
• W1993358922 countsByYear W19933589222016 @default.
• W1993358922 countsByYear W19933589222017 @default.
• W1993358922 countsByYear W19933589222018 @default.
• W1993358922 countsByYear W19933589222019 @default.
• W1993358922 countsByYear W19933589222020 @default.
• W1993358922 crossrefType "journal-article" @default.
• W1993358922 hasAuthorship W1993358922A5027520438 @default.
• W1993358922 hasAuthorship W1993358922A5037638547 @default.
• W1993358922 hasAuthorship W1993358922A5040919280 @default.
• W1993358922 hasAuthorship W1993358922A5042750362 @default.
• W1993358922 hasAuthorship W1993358922A5046487127 @default.
• W1993358922 hasAuthorship W1993358922A5047371947 @default.
• W1993358922 hasAuthorship W1993358922A5048407860 @default.
• W1993358922 hasAuthorship W1993358922A5049392699 @default.
• W1993358922 hasAuthorship W1993358922A5050470835 @default.
• W1993358922 hasAuthorship W1993358922A5056181653 @default.
• W1993358922 hasAuthorship W1993358922A5058498811 @default.
• W1993358922 hasAuthorship W1993358922A5073117349 @default.
• W1993358922 hasAuthorship W1993358922A5076840816 @default.
• W1993358922 hasAuthorship W1993358922A5091307002 @default.
• W1993358922 hasConcept C102230213 @default.
• W1993358922 hasConcept C104317684 @default.
• W1993358922 hasConcept C126322002 @default.
• W1993358922 hasConcept C134018914 @default.
• W1993358922 hasConcept C141035611 @default.
• W1993358922 hasConcept C169760540 @default.
• W1993358922 hasConcept C25498285 @default.
• W1993358922 hasConcept C2775838275 @default.
• W1993358922 hasConcept C2776151105 @default.
• W1993358922 hasConcept C2776914184 @default.
• W1993358922 hasConcept C2777615887 @default.
• W1993358922 hasConcept C2779134260 @default.
• W1993358922 hasConcept C2779830541 @default.
• W1993358922 hasConcept C2780596555 @default.
• W1993358922 hasConcept C2780775167 @default.
• W1993358922 hasConcept C55493867 @default.

• next