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- W1993366516 abstract "Our laboratory recently reported a novel prion [SWI+], in the budding yeast Saccharomyces cerevisiae. [SWI+] is the prion form of Swi1, a component of the SWI/SNF chromatin-remodeling complex. Cells harboring [SWI+] exhibit a partial loss-of-function phenotype for SWI/SNF, which can be easily assayed by poor growth on some non-fermentable carbon sources such as raffinose. Swi1 is unique among yeast prion proteins for its nuclear localization and the fact that it comprises part of a large, multi-subunit protein complex. The discovery of [SWI+] demonstrates for the first time a link between prion function and chromatin remodeling, implying a possible role for prions in gene regulation. We believe that the unique features of this novel yeast prion will provide new insight into prion biology." @default.
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- W1993366516 date "2008-10-01" @default.
- W1993366516 modified "2023-09-25" @default.
- W1993366516 title "New insights into prion biology from the novel [<i>SWI</i><sup>+</sup>] system" @default.
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- W1993366516 doi "https://doi.org/10.4161/pri.2.4.8069" @default.
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