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• W1993374776 abstract "In this review, we discuss the central role of fibroblast growth factor (FGF) signaling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogenesis." @default.
• W1993374776 created "2016-06-24" @default.
• W1993374776 creator A5017487346 @default.
• W1993374776 creator A5023006263 @default.
• W1993374776 creator A5032094873 @default.
• W1993374776 creator A5088912523 @default.
• W1993374776 date "2013-12-17" @default.
• W1993374776 modified "2023-10-16" @default.
• W1993374776 title "Fibroblast growth factor signaling in mammalian tooth development" @default.
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