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- W1993384327 abstract "It is widely appreciated that there is significant inter-individual variability in pain sensitivity, yet only a handful of contributing genetic variants have been identified. Computational genetic mapping and quantitative trait locus analysis suggested that variation within the gene coding for the β3 subunit of the Na+,K+-ATPase pump (Atp1b3) contributes to inter-strain differences in the early phase formalin pain behavior. Significant strain differences in Atp1b3 gene expression, β3 protein expression, and biophysical properties of the Na+,K+ pump in dorsal root ganglia neurons from resistant (A/J) and sensitive (C57BL/6J) mouse strains supported the genetic prediction. Furthermore, in vivo siRNA knockdown of the β3 subunit produced strain-specific changes in the early phase pain response, completely rescuing the strain difference. These findings indicate that the β3 subunit of the Na+,K+-ATPase is a novel determinant of nociceptive sensitivity and further supports the notion that pain variability genes can have very selective effects on individual pain modalities." @default.
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- W1993384327 date "2009-08-01" @default.
- W1993384327 modified "2023-09-23" @default.
- W1993384327 title "The β3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test" @default.
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- W1993384327 doi "https://doi.org/10.1016/j.pain.2009.04.028" @default.
- W1993384327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2744953" @default.
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