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- W1993389344 abstract "The incorporation of acetate into long-chain fatty acids by cell-free extracts of the H37Ra strain of Mycobacterium tuberculosis is markedly stimulated by the presence of other fatty acids; the stimulation is maximal when octanoate is added to the system. A partially-purified enzyme system catalyzes the avidin-insensitive elongation of octanoyl-CoA by acetyl-CoA. In the absence of acetyl-CoA, acyl-CoA's such as octanoyl-CoA or decanoyl-CoA are incorporated directly into fatty acids by what appears to be intermolecular condensations. Thus, [1-14C] octanoyl-CoA yields C16, and and C24 fatty acids with one-half and one-third, respectively, of the 14C in the carboxyl carbon. We suggest the possibility that, in M. tuberculosis, synthesis of long-chain fatty acids may be accomplished through direct condensation of shorter chain length acyl-CoA's rather than only through a stepwise elongation mechanism." @default.
- W1993389344 created "2016-06-24" @default.
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- W1993389344 date "1965-06-01" @default.
- W1993389344 modified "2023-10-04" @default.
- W1993389344 title "Direct incorporation of octanoate into long-chain fatty acids by soluble enzymes of Mycobacterium tuberculosis" @default.
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- W1993389344 doi "https://doi.org/10.1016/0005-2760(65)90144-x" @default.
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