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- W1993392215 abstract "Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by the intestinal mucosa in response to nutrient ingestion. Although GLP-1 has multiple potentially beneficial effects, it is unsuitable as a therapy in Type 2 diabetes due to its short half-life. Liraglutide is an analog of human GLP-1 with high (97%) sequence homology, but has protracted pharmacokinetics as a result of aggregation at its injection site, albumin binding in the circulation and reduced susceptibility to enzymatic degradation. Liraglutide has glucose-lowering effects spanning 24 h, with improvements in fasting and postprandial glucose levels. In clinical studies, liraglutide has achieved reductions in HbA1c of up to 1.6% when used as monotherapy in drug-naive subjects. The incidence of hypoglycemia with liraglutide treatment is relatively low, perhaps reflecting a glucose dependency of its insulinotropic action. Liraglutide also has clinically relevant effects on body weight, with mean reductions of 2–3 kg occurring in large cl..." @default.
- W1993392215 created "2016-06-24" @default.
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- W1993392215 date "2009-03-01" @default.
- W1993392215 modified "2023-09-24" @default.
- W1993392215 title "Liraglutide: a human GLP-1 analog for Type 2 diabetes" @default.
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