FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993394492> ?p ?o ?g. }

• W1993394492 endingPage "18763" @default.
• W1993394492 startingPage "18755" @default.
• W1993394492 abstract "At the nerve terminal, neurotransmitter release is triggered by Ca(2+) influx through voltage-gated Ca(2+) channels (VGCCs). During postnatal development, VGCC subtypes in the nerve terminal switch at many synapses. In immature rodent cerebella, N-type and P/Q-type VGCCs mediate GABAergic neurotransmission from Purkinje cells (PCs) to deep nuclear cells, but as animals mature, neurotransmission becomes entirely P/Q-type dependent. We reproduced this developmental switch in rat cerebellar slice culture to address the underlying mechanism. Chronic block of cerebellar neuronal activity with tetrodotoxin (TTX) in slice culture, or in vivo, reversed the switch, leaving neurotransmission predominantly N-type channel-dependent. Brain-derived neurotrophic factor or neurotrophin-4 rescued this TTX effect, whereas pharmacological blockade of neurotrophin receptors mimicked the TTX effect. In PC somata, unlike in presynaptic terminals, TTX had no effect on the proportion of Ca(2+) channel subtype currents. We conclude that neuronal activity activates the neurotrophin-TrkB signaling pathway, thereby causing the N-to-P/Q channel switch in presynaptic terminals." @default.
• W1993394492 created "2016-06-24" @default.
• W1993394492 creator A5001341469 @default.
• W1993394492 creator A5061107212 @default.
• W1993394492 creator A5063750053 @default.
• W1993394492 date "2013-11-27" @default.
• W1993394492 modified "2023-10-16" @default.
• W1993394492 title "Activity-Dependent Neurotrophin Signaling Underlies Developmental Switch of Ca2+ Channel Subtypes Mediating Neurotransmitter Release" @default.
• W1993394492 cites W1522205897 @default.
• W1993394492 cites W1523938232 @default.
• W1993394492 cites W1531970366 @default.
• W1993394492 cites W1532382772 @default.
• W1993394492 cites W1537065123 @default.
• W1993394492 cites W1839710879 @default.
• W1993394492 cites W1955716838 @default.
• W1993394492 cites W1975923329 @default.
• W1993394492 cites W1980003647 @default.
• W1993394492 cites W1980325410 @default.
• W1993394492 cites W1988937009 @default.
• W1993394492 cites W1989768699 @default.
• W1993394492 cites W2006374456 @default.
• W1993394492 cites W2007589527 @default.
• W1993394492 cites W2021789384 @default.
• W1993394492 cites W2021829541 @default.
• W1993394492 cites W2025853041 @default.
• W1993394492 cites W2032255062 @default.
• W1993394492 cites W2037812600 @default.
• W1993394492 cites W2037844026 @default.
• W1993394492 cites W2046523948 @default.
• W1993394492 cites W2047397502 @default.
• W1993394492 cites W2052006707 @default.
• W1993394492 cites W2058022492 @default.
• W1993394492 cites W2063551274 @default.
• W1993394492 cites W2069172889 @default.
• W1993394492 cites W2073772517 @default.
• W1993394492 cites W2075911019 @default.
• W1993394492 cites W2076801049 @default.
• W1993394492 cites W2079054696 @default.
• W1993394492 cites W2080902377 @default.
• W1993394492 cites W2082386266 @default.
• W1993394492 cites W2085323232 @default.
• W1993394492 cites W2091316910 @default.
• W1993394492 cites W2096156320 @default.
• W1993394492 cites W2098037389 @default.
• W1993394492 cites W2099683418 @default.
• W1993394492 cites W2112906768 @default.
• W1993394492 cites W2124595526 @default.
• W1993394492 cites W2128125306 @default.
• W1993394492 cites W2131921751 @default.
• W1993394492 cites W2139565721 @default.
• W1993394492 cites W2140592106 @default.
• W1993394492 cites W2142325305 @default.
• W1993394492 cites W2143768456 @default.
• W1993394492 cites W2144435898 @default.
• W1993394492 cites W2149858533 @default.
• W1993394492 cites W2150647941 @default.
• W1993394492 cites W2162267856 @default.
• W1993394492 cites W2162562181 @default.
• W1993394492 cites W2165544326 @default.
• W1993394492 cites W2171405755 @default.
• W1993394492 cites W3148793713 @default.
• W1993394492 doi "https://doi.org/10.1523/jneurosci.3161-13.2013" @default.
• W1993394492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618703" @default.
• W1993394492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24285882" @default.
• W1993394492 hasPublicationYear "2013" @default.
• W1993394492 type Work @default.
• W1993394492 sameAs 1993394492 @default.
• W1993394492 citedByCount "22" @default.
• W1993394492 countsByYear W19933944922014 @default.
• W1993394492 countsByYear W19933944922015 @default.
• W1993394492 countsByYear W19933944922016 @default.
• W1993394492 countsByYear W19933944922017 @default.
• W1993394492 countsByYear W19933944922018 @default.
• W1993394492 countsByYear W19933944922019 @default.
• W1993394492 countsByYear W19933944922021 @default.
• W1993394492 countsByYear W19933944922022 @default.
• W1993394492 countsByYear W19933944922023 @default.
• W1993394492 crossrefType "journal-article" @default.
• W1993394492 hasAuthorship W1993394492A5001341469 @default.
• W1993394492 hasAuthorship W1993394492A5061107212 @default.
• W1993394492 hasAuthorship W1993394492A5063750053 @default.
• W1993394492 hasBestOaLocation W19933944921 @default.
• W1993394492 hasConcept C134018914 @default.
• W1993394492 hasConcept C160539049 @default.
• W1993394492 hasConcept C169760540 @default.
• W1993394492 hasConcept C170493617 @default.
• W1993394492 hasConcept C178790620 @default.
• W1993394492 hasConcept C185592680 @default.
• W1993394492 hasConcept C18699975 @default.
• W1993394492 hasConcept C200170125 @default.
• W1993394492 hasConcept C2776219046 @default.
• W1993394492 hasConcept C2776741303 @default.
• W1993394492 hasConcept C519063684 @default.
• W1993394492 hasConcept C529278444 @default.
• W1993394492 hasConcept C55493867 @default.
• W1993394492 hasConcept C56703729 @default.
• W1993394492 hasConcept C86803240 @default.
• W1993394492 hasConcept C92020748 @default.

• next