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- W1993408032 abstract "Four groups of 7 male Wistar rats were treated as follows : one group of normal and another of streptozotocin-induced diabetic rats were administered Bay g 6575 orally (20 mg/kg/day); the other two groups of normal and diabetic rats did not receive any drug. From these animals aortic tissue was removed for PGI2 bioassay based upon its platelet aggregation inhibitory effect. The diabetic rats released significantly less PGI2 than the controls (p < 0.005). The antithrombotic compound Bay g 6575 increased significantly the release of PGI2 in normal (p < 0.05) and diabetic animals (p < 0.02). This study confirms previous reports concerning the decrease of PGI2 release in experimentally induced diabetes, and demonstrates that it can be stimulated by the drug Bay g 6575, a compound with marked antithrombotic activity in experimental models." @default.
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- W1993408032 date "1980-08-01" @default.
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- W1993408032 title "Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound bay g 6575" @default.
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- W1993408032 doi "https://doi.org/10.1016/0049-3848(80)90038-9" @default.
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