FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993416088> ?p ?o ?g. }

• W1993416088 abstract "Abstract #4080 Background:
 Variations in estrogen metabolism may be associated with increased breast cancer risk. Women who have preferential metabolism via 16α-hydroxylation are reported to have a higher risk of developing breast cancer compared to women who have preferential metabolism via 2α-hydroxylation. Profiling estrogen metabolites may identify women who are more likely to develop breast cancer within a population of women with known risk factors. Our aim was to evaluate estrogen metabolism in a group of high risk women.
 Methods:
 Women were recruited from the Magee-Women9s Hospital High Risk Breast Cancer program. Risk factors included first degree family history, atypia, fibrocystic breast disease, BRCA1/2, Ashkenazi Jewish descent. Urine 2:16 OHE ratios were compared among the high risk group, an average risk control group, and a group of women with breast cancer. We also evaluated the relationship between urine 2:16 OHE ratios and epidemiological risk factors including BMI, alcohol use, smoking history and first degree family history.
 Results:
 There were 65 high risk patients, 30 breast cancer patients, and 41 controls. The Kruskaul-Wallis rank test and Wilcoxon rank-sum test were used for analysis. There was a significant difference in 2:16 OHE ratios among all three groups, p=0.0001. Urine 2:16 OHE ratios were lower in the high risk group (median 1.15) compared to the control group (2.22), p=0.00, and were lower in the breast cancer group (1.09) compared to the controls, p=0.00. There was a difference in BMI among all three groups, p=0.002. Overall, the 2:16 OHE ratio was positively associated with BMI, p=0.0006, and with alcohol use, p=0.02. Smoking history did not differ among all groups, and there was no association between smoking history and 2:16 OHE ratio. Within the high risk group, family history was not associated with 2:16 OHE ratio.
 Conclusions:
 Our research suggests that there is an association between lower urine 2:16 OHE ratios and high risk breast cancer. This association may be linked to specific risk factors such as BMI and alcohol use. This information may help to further elucidate the clinical relevance of using urinary 2:16 OHE ratios as clinical markers and prognostic indicators in this population. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4080." @default.
• W1993416088 created "2016-06-24" @default.
• W1993416088 creator A5022620022 @default.
• W1993416088 creator A5024115011 @default.
• W1993416088 creator A5032422466 @default.
• W1993416088 creator A5041098739 @default.
• W1993416088 creator A5042627530 @default.
• W1993416088 creator A5047330944 @default.
• W1993416088 creator A5083465867 @default.
• W1993416088 date "2009-01-15" @default.
• W1993416088 modified "2023-09-27" @default.
• W1993416088 title "Urinary estrogen metabolites in patients at high risk for breast cancer." @default.
• W1993416088 doi "https://doi.org/10.1158/0008-5472.sabcs-4080" @default.
• W1993416088 hasPublicationYear "2009" @default.
• W1993416088 type Work @default.
• W1993416088 sameAs 1993416088 @default.
• W1993416088 citedByCount "1" @default.
• W1993416088 crossrefType "proceedings-article" @default.
• W1993416088 hasAuthorship W1993416088A5022620022 @default.
• W1993416088 hasAuthorship W1993416088A5024115011 @default.
• W1993416088 hasAuthorship W1993416088A5032422466 @default.
• W1993416088 hasAuthorship W1993416088A5041098739 @default.
• W1993416088 hasAuthorship W1993416088A5042627530 @default.
• W1993416088 hasAuthorship W1993416088A5047330944 @default.
• W1993416088 hasAuthorship W1993416088A5083465867 @default.
• W1993416088 hasConcept C121608353 @default.
• W1993416088 hasConcept C126322002 @default.
• W1993416088 hasConcept C143998085 @default.
• W1993416088 hasConcept C146304588 @default.
• W1993416088 hasConcept C2776601875 @default.
• W1993416088 hasConcept C2777164284 @default.
• W1993416088 hasConcept C2779880527 @default.
• W1993416088 hasConcept C2780026642 @default.
• W1993416088 hasConcept C2781179581 @default.
• W1993416088 hasConcept C2908647359 @default.
• W1993416088 hasConcept C29456083 @default.
• W1993416088 hasConcept C530470458 @default.
• W1993416088 hasConcept C71924100 @default.
• W1993416088 hasConcept C99454951 @default.
• W1993416088 hasConceptScore W1993416088C121608353 @default.
• W1993416088 hasConceptScore W1993416088C126322002 @default.
• W1993416088 hasConceptScore W1993416088C143998085 @default.
• W1993416088 hasConceptScore W1993416088C146304588 @default.
• W1993416088 hasConceptScore W1993416088C2776601875 @default.
• W1993416088 hasConceptScore W1993416088C2777164284 @default.
• W1993416088 hasConceptScore W1993416088C2779880527 @default.
• W1993416088 hasConceptScore W1993416088C2780026642 @default.
• W1993416088 hasConceptScore W1993416088C2781179581 @default.
• W1993416088 hasConceptScore W1993416088C2908647359 @default.
• W1993416088 hasConceptScore W1993416088C29456083 @default.
• W1993416088 hasConceptScore W1993416088C530470458 @default.
• W1993416088 hasConceptScore W1993416088C71924100 @default.
• W1993416088 hasConceptScore W1993416088C99454951 @default.
• W1993416088 hasLocation W19934160881 @default.
• W1993416088 hasOpenAccess W1993416088 @default.
• W1993416088 hasPrimaryLocation W19934160881 @default.
• W1993416088 hasRelatedWork W16042780 @default.
• W1993416088 hasRelatedWork W1972072776 @default.
• W1993416088 hasRelatedWork W1989539191 @default.
• W1993416088 hasRelatedWork W2053768367 @default.
• W1993416088 hasRelatedWork W2111068972 @default.
• W1993416088 hasRelatedWork W2126508496 @default.
• W1993416088 hasRelatedWork W2147201243 @default.
• W1993416088 hasRelatedWork W2160525662 @default.
• W1993416088 hasRelatedWork W2163151567 @default.
• W1993416088 hasRelatedWork W2301993282 @default.
• W1993416088 hasRelatedWork W2316846755 @default.
• W1993416088 hasRelatedWork W2357674360 @default.
• W1993416088 hasRelatedWork W2740884772 @default.
• W1993416088 hasRelatedWork W2748446964 @default.
• W1993416088 hasRelatedWork W2926179505 @default.
• W1993416088 hasRelatedWork W2953722983 @default.
• W1993416088 hasRelatedWork W2955397216 @default.
• W1993416088 hasRelatedWork W2955871838 @default.
• W1993416088 hasRelatedWork W2980647009 @default.
• W1993416088 hasRelatedWork W60125322 @default.
• W1993416088 isParatext "false" @default.
• W1993416088 isRetracted "false" @default.
• W1993416088 magId "1993416088" @default.
• W1993416088 workType "article" @default.