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• W1993423613 abstract "Abstract Chinese hamster ovary cells in vitro were heated (42.5°C) before, during, or after X-irradiation (5 Gy). First, a slight degree of radioprotection was observed when cells were irradiated in acidic medimn compared to irradiation in alkaline medium; i.e., 10 Gy reduced survival to 0.0035 at pH 6.75 compared to 0.0010 at pH 7.45. Second, survival increased independent of pH as the time between irradiation and subsequent heat treatment was increased. Third, both heat treatments alone and combined heat and irradiation treatments in acidic medium produced more cell killing than treatments in alkaline medium; the amount of recovery from heat damage which subsequently interacted with radiation damage decreased as the pH was decreased from 7.40 to 6.70. Furthermore, inhibition of recovery was reflected primarily as an increase in the slope of the radiation survival curve; i.e., heating for 60 min 150 min before irradiation decreased the D 0 from 1.00 Gy for cells heated and irradiated under alkaline conditions ad to 0.70 Gy for cells treated under acidic conditions. The extravolation numbers were 5 and 6 for the respective curves." @default.
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• W1993423613 date "1981-02-01" @default.
• W1993423613 modified "2023-09-27" @default.
• W1993423613 title "The effect of pH on hyperthermic and x ray induced cell killing" @default.
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• W1993423613 doi "https://doi.org/10.1016/0360-3016(81)90439-9" @default.
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