Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993430879> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1993430879 endingPage "756" @default.
- W1993430879 startingPage "749" @default.
- W1993430879 abstract "Incubation of primary cultures of rat hepatocytes with the local anesthetics, procaine or lidocaine, had little or no effect on insulin uptake or degradation but caused an inhibition of insulin-stimulated glycogenesis. While exposure of cultures to the amines, monodansylcadaverine or CH3NH2, resulted in significant dose-dependent decreases in glycogenesis, only monodansylcadaverine (an inhibitor of receptor clustering) decreased uptake whereas CH3NH2 (a lysosomotropic agent) caused increases in both insulin uptake and degradation. When cells were treated with agents which inhibit glycolysis (NaF, 2-deoxy-D-glucose) or oxidative metabolism (2,4-dinitrophenol, carbonyl cyanide m-chlorophenyl hydrazone, NaN3, antimycin A), pronounced inhibitions of each of the bioactivities studied (syntheses of glycogen, protein, lipid) were observed, but only the glycolytic inhibitors decreased insulin uptake. These results suggest that insulin is internalized by an endocytotic process involving receptor clustering and requiring metabolic energy derived from glycolysis. The post-receptor biosynthetic processes involved in the expression of the biological activities of insulin (syntheses of glycogen, protein, lipid) require energy produced by oxidative metabolism while the degradation of insulin is carried out by nonlysosomal mechanisms which are not energy-requiring." @default.
- W1993430879 created "2016-06-24" @default.
- W1993430879 creator A5002266685 @default.
- W1993430879 creator A5045961365 @default.
- W1993430879 creator A5069777316 @default.
- W1993430879 creator A5083110762 @default.
- W1993430879 date "1985-10-01" @default.
- W1993430879 modified "2023-09-26" @default.
- W1993430879 title "Role of membranes and energy-producing reactions in cellular processing of insulin in primary cultures of rat hepatocytes" @default.
- W1993430879 cites W10640494 @default.
- W1993430879 cites W2003955148 @default.
- W1993430879 cites W2017119979 @default.
- W1993430879 cites W2022887052 @default.
- W1993430879 cites W2048695488 @default.
- W1993430879 cites W2053656846 @default.
- W1993430879 cites W2071551486 @default.
- W1993430879 cites W2096261634 @default.
- W1993430879 cites W2161106503 @default.
- W1993430879 cites W2402293314 @default.
- W1993430879 cites W2883239271 @default.
- W1993430879 doi "https://doi.org/10.1016/0006-291x(85)91196-9" @default.
- W1993430879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3904755" @default.
- W1993430879 hasPublicationYear "1985" @default.
- W1993430879 type Work @default.
- W1993430879 sameAs 1993430879 @default.
- W1993430879 citedByCount "5" @default.
- W1993430879 crossrefType "journal-article" @default.
- W1993430879 hasAuthorship W1993430879A5002266685 @default.
- W1993430879 hasAuthorship W1993430879A5045961365 @default.
- W1993430879 hasAuthorship W1993430879A5069777316 @default.
- W1993430879 hasAuthorship W1993430879A5083110762 @default.
- W1993430879 hasConcept C109384507 @default.
- W1993430879 hasConcept C112446052 @default.
- W1993430879 hasConcept C134018914 @default.
- W1993430879 hasConcept C17093226 @default.
- W1993430879 hasConcept C178790620 @default.
- W1993430879 hasConcept C185592680 @default.
- W1993430879 hasConcept C192118531 @default.
- W1993430879 hasConcept C20251656 @default.
- W1993430879 hasConcept C2777391703 @default.
- W1993430879 hasConcept C2777499176 @default.
- W1993430879 hasConcept C2777866211 @default.
- W1993430879 hasConcept C2779306644 @default.
- W1993430879 hasConcept C2779965811 @default.
- W1993430879 hasConcept C28859421 @default.
- W1993430879 hasConcept C2982719155 @default.
- W1993430879 hasConcept C518851703 @default.
- W1993430879 hasConcept C55493867 @default.
- W1993430879 hasConcept C57600042 @default.
- W1993430879 hasConcept C62231903 @default.
- W1993430879 hasConcept C86803240 @default.
- W1993430879 hasConceptScore W1993430879C109384507 @default.
- W1993430879 hasConceptScore W1993430879C112446052 @default.
- W1993430879 hasConceptScore W1993430879C134018914 @default.
- W1993430879 hasConceptScore W1993430879C17093226 @default.
- W1993430879 hasConceptScore W1993430879C178790620 @default.
- W1993430879 hasConceptScore W1993430879C185592680 @default.
- W1993430879 hasConceptScore W1993430879C192118531 @default.
- W1993430879 hasConceptScore W1993430879C20251656 @default.
- W1993430879 hasConceptScore W1993430879C2777391703 @default.
- W1993430879 hasConceptScore W1993430879C2777499176 @default.
- W1993430879 hasConceptScore W1993430879C2777866211 @default.
- W1993430879 hasConceptScore W1993430879C2779306644 @default.
- W1993430879 hasConceptScore W1993430879C2779965811 @default.
- W1993430879 hasConceptScore W1993430879C28859421 @default.
- W1993430879 hasConceptScore W1993430879C2982719155 @default.
- W1993430879 hasConceptScore W1993430879C518851703 @default.
- W1993430879 hasConceptScore W1993430879C55493867 @default.
- W1993430879 hasConceptScore W1993430879C57600042 @default.
- W1993430879 hasConceptScore W1993430879C62231903 @default.
- W1993430879 hasConceptScore W1993430879C86803240 @default.
- W1993430879 hasIssue "2" @default.
- W1993430879 hasLocation W19934308791 @default.
- W1993430879 hasLocation W19934308792 @default.
- W1993430879 hasOpenAccess W1993430879 @default.
- W1993430879 hasPrimaryLocation W19934308791 @default.
- W1993430879 hasRelatedWork W1993430879 @default.
- W1993430879 hasRelatedWork W1994667169 @default.
- W1993430879 hasRelatedWork W2063377421 @default.
- W1993430879 hasRelatedWork W2087895518 @default.
- W1993430879 hasRelatedWork W2152300515 @default.
- W1993430879 hasRelatedWork W2403658647 @default.
- W1993430879 hasRelatedWork W2414365068 @default.
- W1993430879 hasRelatedWork W2464007556 @default.
- W1993430879 hasRelatedWork W2555360169 @default.
- W1993430879 hasRelatedWork W27277634 @default.
- W1993430879 hasVolume "132" @default.
- W1993430879 isParatext "false" @default.
- W1993430879 isRetracted "false" @default.
- W1993430879 magId "1993430879" @default.
- W1993430879 workType "article" @default.